Chronic Myeloid Leukaemia

Question 1

Chronic Myeloid Leukaemia;

Rare in ?, occurs most commonly in people aged ?-?
The ? ? is present in 95% of people with CML.
o This represents a ? prognosis than those without.

Answer 1

children
40-60
phil chrom
better

Question 2

Symptoms;

30% are detected by chance, with ? ? symptoms the most common
presentation.
Other symptoms are ? due to purine breakdown, and ? discomfort due to ? enlargement.
On examination, there is often ?splenomegaly, ?, and signs of anaemia/?.

Answer 2

insidious b
gout
abdo
splenic
massive
hepatomegaly
thrombocytopenia

Question 3

Investigations;

FBC: ? very high, raised across the whole spectrum of myeloid cells.
? ?: spectrum of myeloid cells.
Bone marrow biopsy: ?.
CT/ ?.
Cytogenetic analysis of ? / ? for the Philadelphia chromosome

Answer 3

wcc
blood film
hypercellular
pet
blood/marrow

Question 4

Management;

? chemotherapy has response rates >90%, and is first line.
? cell ? is the only treatment that may achieve remission, but carries significant ?/?.

Answer 4

imatinib
stem
transplantation
mort/morb

Question 5

Prognosis;

Median survival ? years. There are three phases;
o ? Phase: Few symptoms, lasts for ?.
o ? Phase: Increasing symptoms, difficulty controlling counts.
o ? transformation: Features of ?leukaemia, eventual death

Answer 5

6
chronic
years
accelerated
blast
acute