Immune Thrombocytopenia

Question 1

Thrombocytopenia can be due to reduced platelet ? in the ? ?, or excessive ? ? of platelets.

Answer 1

prod
bm
peripheral destruction

Question 2

Reduced production;

? anaemia.
Marrow ?.
Marrow ?.

Answer 2

aplastic
infiltration
suppression

Question 3

Excess destruction

? ? ?: ITP.
Other autoimmune causes: ?, ?, viruses.
? ? ?: TTP.
? ? ?: HUS.
Sequestration: ?.

Answer 3

idiopathic thrombocytopenic purpura
SLE CLL
Thrombotic thrombocytopenic purpura
haemolytic uraemic
hypersplenism

Question 4

Presentation is with ? bleeding;

?/? of the skin.
?/menorrhagia

Answer 4

mucocutaneous
bruising/purpura
epistaxis

Question 5

Immune thrombocytopenic purpura;

In ?, ITP is usually acute and self-limiting following a virus or
immunisation.
In ? the presentation is usually less acute, classically in women with
other autoimmune disorders.

Answer 5

kids

adults

Question 6

Investigations

FBC: only ? seen.
Bone marrow examination: not usually performed in ?, but normal/increased ? numbers found, otherwise normal.
Platelet ?: positive in 70% patients, but does not confirm diagnosis.

Answer 6

thrombocytopenia
kids
megakaryocytes
autoantibodies

Question 7

Management
? are not usually treated.
If clinically necessary, they may be treated with ? or ????.
? thrombocytopenia is rare, and requires specialist management.

Answer 7

kids
pred
IVIG
chronic

Question 8

Mx
In adults, ? are first line.
o ???? can be used if a ? rise in platelets are required.
o ? may be second line.
Platelet transfusions are reserved for extreme ?.

Answer 8

corticosteroids
IVIG
rapid
splenectomy
haemorrhage