DIC

Question 1

There is thrombotic ? of the ?microvasculature.
The simultaneous depletion of ? ? and consumption of ? leads to haemorrhage.
Eventually ? failure develops.

Answer 1

occlusion
arterial
clotting factors
platelets
organ

Question 2

Causes;
o ?.
o ?.
o ?.
o Obstetric complication (amniotic fluid ?, ?-?).
o Severe ? failure.
o Tissue destruction (?/?).
o ?/ immunogenic stimuli.

Answer 2

infection
malignancy
trauma
emboli
pre-eclampsia
liver
pancreatitis, burns
toxic

Question 3

Clinical features;

?.
Excessive ? from any sites (e.g. venepuncture wounds).
? failure.

Answer 3

bruising
bleeding
renal

Question 4

Investigation;

Low ?, ? fibrinogen.
Raised ? & ?.
Raised ?.
Blood film : ? RBCs (schistocytes).

Answer 4

platelets
low
pt, aptt
d-dimer
broken

Question 5

Treatment;

Treat the cause.
Aggressive ?, replacing ?, coagulation factors (with ?) and fibrinogen (with ?).
Protein ?: reduces mortality in multi-organ failure/ severe ? .

Answer 5

resus
platelets
FFP
cryoprecipitate
C
sepsis