Thrombolytic Agents

Question 1

CCM 3rd Edt

Answer 1

Chapter 166 - Thrombolytic Agents

Question 2

What is the central enzyme responsible for thrombus degradation

Answer 2

Plasmin

Question 3

What is the MOA of plasmin ?

Answer 3

cleaves the lysine and arginine residues of fibrin and fibrinogen.
Cross-linked fibrin is degraded more slowly.
D-dimer fragments are created during cleaving

Question 4

What are fibrinolytic inhibitors?

Answer 4

plasminogen activator inhibitor-1 (PAI-1) - inhibits t-PA and u-PA
α2 anti-plasmin inhibits plasmin - synthesised in the liver
Thrombin-activatable fibrinolysis inhibitor (TAFI) - produced by the liver and activated by the thrombin/thrombomodulin complex and by plasmin - inhibits fibrinolysis

Question 5

What is a difference between streptokinase and urokinase?

Answer 5

Uro is more fibrin specific - decreasing fibrinogen destruction and therefore limiting bleeding complications.