Anaemia in the ICU Flashcards
What is the DO2 equation?
DO2 = CO x CaO2
What makes up the CaO2?
([HB) x 1.34 x SaO2) + (0.003 x PaO2)
How many O2 molecules can be transported per haemoglobin ?
4
under normal conditions how much higher is DO2 than VO2?
4 times
What is the catalyst of erythropoietin synthesis?
Tissue hypoxia
What s=is the lifespan of a canine and feline RBC
canine 104 feline 73
How do animals physiologically adapt to anaemia
compensatory increase in cardiac output associated with enhanced sympathetic tone and decreased blood viscosity.
peripheral oxygen extraction tends to increase as the severity of anemia worsens.1 There is a rightward shift of the oxygen dissociation curve, mediated predominantly by increasing 2,3-DPG in dogs
what are the three main causes of anaemia
haemorrhage, haemolysis and dyserythropoiesis
How accurate is polychromasia for Dx of regeneration in dogs?
77% - shook
Why does hypervolaemia develop in chronic anaemia?
Due to activation of RAAS to improve CO and reduce viscosity
What are likely factors resulting in hospital acquired anaemia?
phlebotomy, resus strategies, blunted erythropoietic response due to systemic inflammation. (TNFa, IL-1, IL-6, interferon-a, interferon-b, interferon-c)
