Haemostatic Drugs

Question 1

CCM 3rd Edt

Answer 1

Chapter 167 - Haemostatic Drugs

Question 2

How does Desmopressin work?

Answer 2

Nil V1 activity. enhances vWF release
No evidence it’s helpful in bleeding that is not associated with platelet dysfunction

Question 3

How does yunnan baiyao work?

Answer 3

not fully known - may stimulate platelet activation and alpha granule release
Anti-inflammatory effects from cox, lox and AA inhibition.
Minimal evidence to suggest benefit. Nil evidence to suggest harm

Question 4

What is cryoprecipitate?

Answer 4

Made from FFP. Contains high quantities of vWF, FV, FVIII, fibrinogen

Question 5

Plasma-Based Coagulopathies

Question 6

Discuss the use of rFVIIa in veterinary species.

Answer 6

used to treat haemophilia A and B - When rhVIIa is given at high doses, causes coagulation by bypassing the intrinsic pathway and initiates hemostasis by increasing the interaction between FVII and tissue factor (TF). A second mechanism, known as the bypass effect, is TF-independent. rFVIIa binds directly to the phospholipid membrane of activated platelets, which activates FX.
Dogs develop Abs to human FVII within two weeks.
Canine rFVII has ben experimentally looked into

Question 7

How do TXA and aminocaproic acid work

Answer 7

block the lysine binding site of