Thiazolidinediones (Glitazones) (Oral Hypoglycemics)

Question 1

Thiazolidinediones (Glitazones)

Answer 1

pioglitazone (Actos)

rosiglitazone (Avandia)

Question 2

Therapeutic Uses
pioglitazone (Actos)
rosiglitazone (Avandia)

Answer 2

Type 2 diabetes

Question 3

Mechanism of Action
pioglitazone (Actos)
rosiglitazone (Avandia)

Answer 3

Activates the peroxisome proliferators-activated receptor gamma (PPAR-gamma) receptors.
Basically it turns on insulin-responsive genes that help regulate carbohydrate and lipid
metabolism; increasing insulin sensitivity. This takes several weeks for benefits to be seen

Question 4

Adverse Effects
pioglitazone (Actos)
rosiglitazone (Avandia)

Answer 4

Can cause fluid retention, edema (precaution against use in mild CHF & contraindicated in severe CHF). May cause resumption of ovulation in pts taking oral contraceptives. Raises HDL and lowers triglycerides, which are good, but may also raise LDL. Probably NOT hepatotoxic like troglitazone was, but liver function tests may still be monitored

Question 5

Administration
pioglitazone (Actos)
rosiglitazone (Avandia)

Answer 5

Taken orally with food to enhance bioavailability