Incretin mimetics

Question 1

Incretin mimetics

Answer 1

exenatide (Byetta)

liraglutide (Victosa)

Question 2

Therapeutic Uses
exenatide (Byetta)
liraglutide (Victosa)

Answer 2

Type 2 diabetes

Question 3

Mechanism of Action
exenatide (Byetta)
liraglutide (Victosa)

Answer 3

Synthetic version of glucagon-like peptide-1 (GLP-1); normally, GLP-1 is released from cells
in the GI tract after a meal. GLP-1 increases insulin release and reduces production of
glucose by the liver as well as slows gastric emptying and suppresses appetite.

Question 4

Administration
exenatide (Byetta)
liraglutide (Victosa)

Answer 4

Enenatid-Administered SQ twice daily before the morning and evening meals
Liraglutide-Administered SQ once daily before a meal

Question 5

Adverse Effects
exenatide (Byetta)
liraglutide (Victosa)

Answer 5

Hypoglycemia (14 – 35%), nausea (45%), diarrhea (13%), feeling jittery (9%). Reduce
dose of oral medications when starting to avoid hypoglycemia