Thiazolidinediones

Question 1

Pioglitizone (actos) is part of what medication class?

Answer 1

thiazolidinediones

Question 2

What is the MOA of pioglitizone (Actos)

Answer 2

Increases insulin sensitivity (increases expression of proteins necessary for insulin use in cells)
Reduce hepatic production of glucose
Mild affect on lipids

Question 3

True or false

Because of their MOA, thiazolidinediones frequently cause hypoglycemic events

Answer 3

False - they do not increase insulin production and have minimal risk for hypoglycemic events

Question 4

The ADA currently recommends that thiazolidinediones be used as _________ therapy

Answer 4

adjunctive
- when patients cannot reach A1c goals with lifestyle changes and metformin alone

Question 5

Pioglitazone is associated with weight _______

Answer 5

gain

Question 6

What side effects of pioglitazone make it contraindicated in patients with HF?

Answer 6

Edema
Hypertension

Question 7

True or false

Pioglitazone is metabolized by the CYP450 system and may lead to a wide range of pharmacokinetic interactions

Answer 7

True