Diuretics Flashcards
Name example medications from the loop diuretics
Lasix
Bumex
What is the site of action of the loop diuretics
ascending loop of henle
True or false:
Loop diuretics are poorly absorbed via the oral route of administration
False
True or false
Loop diuretics have a brisk onset of action
True
Describe the MOA of loop diuretics
Prevent sodium reabsorption from the ascending loop of henle
this also prevents reabsorption of water, leading to diuresis
Name a major side effect of loop diuretics
Decreased serum potassium
Name several thiazide diuretics
hydrochlorothiazide
chlorthalidone
metolazone
What is the site of action of the thiazide diuretics
Distal convoluted tubule
What is the mechanism of action of the thiazide diuretics
prevents sodium reabsorption in the distal convoluted tubule
also leads to less water reabsorption and causes diuresis
True or false
The thiazide diuretics have a less brisk onset of action than the loop diuretics, but generally last longer
True
Name an aldosterone antagonist diuretic
spironolactone
Spironolactone is a ____ sparing diuretic
potassium
What is the site of action of aldosterone antagonists
distal convoluted tubule
What is the mechanism of action of spironolactone
inhibits aldosterone action, causing increased sodium and water excretion, while reabsorbing potassium
What are notable side effects of the aldosterone antagonists
Gynecomastia
Increased serum potassium levels
