Cardiac Glycosides

Question 1

Name a cardiac glycoside

Answer 1

Digoxin

Question 2

What effect does digoxin have on inotropy

Answer 2

Increases

Question 3

What effect does digoxin have on chronotropy

Answer 3

decreases

Question 4

What is the mechanism of action of digoxin?

Answer 4

Inhibits the Na/K pump, leading to increased calcium concentrations inside the cell

Question 5

True or false:

Digoxin remains among the first line agents for treatment of heart failure

Answer 5

False

Question 6

Digoxin has a very ________ therapeutic index

Answer 6

narrow

high risk for toxicity!

Question 7

What are common side effects of digoxin?

Answer 7

GI: nausea, vomiting

digoxin does not selectively bind to cardiac muscle

Question 8

True or false:

Digoxin is indicated for use in ventricular arrhythmias

Answer 8

False
although it has negative chronotropic effects, it may potentiate some types of tachyarrhythmias

Question 9

What is the antidote for digoxin toxicity

Answer 9

Digibind