DPP 4 inhibitors

Question 1

What medications fall into the DPP4 inhibitor class

Answer 1

GLIPTINs
* linagliptin (tradjenta)
* saxagliptin (onglyza)
* sitagliptin (Januvia)

Question 2

What is the MOA of DPP4 inhibitors

Answer 2

inhibit the breakdown of GLP1 (a hormone responsible for insulin and glucagon secretion)

Question 3

True or false:

DPP-4 inhibitors improve insulin resistance

Answer 3

False - they have no action on insulin resistance

Question 4

what is the location of metabolism for DPP4 inhibitors?

Answer 4

small intestine

Question 5

Current ADA guidelines state that DPP-4 inhibitors should be used as __________ therapy

Answer 5

adjunctive or second line therapy

only exhibit a moderate improvement in glycemic control

Question 6

true or false

DPP-4 inhibitors are not associated with weight gain

Answer 6

true

Question 7

All DPP-4 inhibitors are dependent on renal excretion and should be dose adjusted in renal impairment, except for ________

Answer 7

Linagliptin (Tradjenta)

Question 8

2 common adverse effects of DPP-4 inhibitors are

Answer 8

Arthralgias
Pancreatitis

Question 9

DPP-4 inhibitors improve A1c by _______%

Answer 9

<1

Booooo. Dr. Busti don’t really like these either

Question 10

DPP-4 inhibitors are generally __________ tolerated

Answer 10

well