CCB Flashcards
Name the non-dihydropyridine CCB’s
Diltiazem
Verpamil
What is the mechanism of action of non-dihydropyridine CCB?
Competitive inhibition of calcium entry into cardiac myocytes (specifically in SA and AV nodes)
there is also some overlap into the smooth muscles of vasculature
What is dromotropy?
The speed of conduction through nodal cells
What effect do non-dihydropyridine CCB’s have on dromotropy?
Decrease
What effect do non-dihydropyridine CCB’s have on inotropy?
Decrease
True or false:
Verapamil and Diltiazem are useful for preventing detrimental cardiac remodeling?
False
they lack the benefits for remodeling possessed by beta blockers
________ is a potential side effect with immediate release formulations of dihydropyridine calcium channel blockers
Reflex tachycardia
physiological attempt at regulating hemodyamics/blood pressure
The vasodilation caused by CCB’s may lead to _____
Peripheral edema
CCB’s may also cause a decrease in calcium in intestinal smooth muscle, leading to ___________
Constipation
_________ is an IV formulation CCB, with an appearance similar to propofol
Cleviprex (clevidipine)
True or false:
An advantage of the CCB’s is that they do not have any effects on the CYP450 system
False
a majority of them are a substrate, an inhibitor, or BOTH!
Nimodipine is a CCB with the unique indication of _________
Ruptured berry aneurysms
CCBs primarily dilate ____________ vessels.
Arterial
CCB’s with __________ are effective in ______________ with hypertension.
Thiazide diuretics
African Americans
Why are CCB’s contraindicated after MI/HF?
Decreased inotropy and decreased preload d/t vasodilation and peripheral edema.
