GLP-1 Agonists

Question 1

What medications are in the GLP-1 agonists class

Answer 1

• Dulaglutide (Trulicity)
• Exanatide (Byetta)
• Liraglutide (Victoza)

Question 2

What is the MOA of GLP-1 Agonists

Answer 2

• mimic GLP-1 incretin hormone to help pancreas relase insulin in response to glucose
• decrease glucagon release
• delay gastric emptying

Question 3

True or false:

GLP-1 agonsists lead to the progression of beta-cell burnout

Answer 3

False - they only augment the action of the pancreas in response to glucose

Question 4

Patients receiving GLP-1 agonists may develop ________ which decrease the effectiveness of these medications

Answer 4

drug antibodies

Question 5

Due to the MOA, GLP-1 agonists may cause __________ and should be avoided in patients with pre-existing _________

Answer 5

• GI upset/nausea/vomitting
• severe GI disease (chrohns, gastroparesis)

Question 6

Dulaglutide (Trulicity) is the only GLP-1 agonists that (does/does not) require renal and hepatic dosing

Answer 6

Does not - other medications in this class should be used cautiously

Question 7

GLP-1 agonists are unique because they are administered via which route?

Answer 7

Subcutaneous injection

Question 8

Black box warning for the GLP-1 agonists:

Answer 8

Increased risk of thyroid or other endocrine cancers

Question 9

compared to the SGLT-2 class and DPP-4 class, GLP-1 agonists help ________ patients achieve goal A1C

Answer 9

MORE! Up to 50-70% of patients on GLP-1 agonists