Therapeutics and infections Flashcards

introduction of the model and general information about this topic

1
Q

What is infection ?

A

The invasion and growth of organism in the body

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2
Q

Types of pathogen ?

A

Bacteria
Viruses
Fungi
Protozoa

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3
Q

treatment of :

  • bacterial
  • fungal
  • viral
A

Bacterial:
–> antibiotic medication

Fungal:
–> Antifungal medication

Viral:
–> Non / antiviral medication

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4
Q

What is bacteria?

A

single-cell organisms without a nucleus

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5
Q

what is viruses

A

microscopic parasites that reproduce by taking over living cells

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6
Q

What is fungi

A

simple organisms that grow as single cells or thread like filaments

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7
Q

What is protozoa ?

A

Single cell organisms with a nucleus

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8
Q

Define selective toxicity

A

The ability of an antimicrobial drug to harm the target microbe without harming the host

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9
Q

What is drug resistance

A

is when the bacteria have a resistance strain from the antibiotics through natural selection and causing antibiotics to not have an effect on them

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10
Q

What is Pharmacokinetics

A

the principles to the safe and effective therapeutic management of drugs in an individual patient

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11
Q

What is Pharmacodynamics

A

How the drug affects the body

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12
Q

Which 4 principles are in the pharmacokinetics?

and what do they do?

A

A –> Absorption - how drug gets into the body
D –> Distribution - where drug goes to in the body
M –> Metabolism - how the body chemically modifies the drug
E –> Excretion - how the body gets rid of the drug

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13
Q

Examples of administration ? (give 5)

A
  • Ocular delivery
  • buccal delivery
  • sublingual delivery
  • oral delivery
  • intravenous delivery
  • intramuscular delivery
  • subcutaneous delivery
  • transdermal delivery
  • pulmonary/ nasal delivery
  • vaginal/ rectal delivery
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14
Q

what is drug absorption

A

the process of drug movement from site of administration towards the bloodstream

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15
Q

How fast will the absorption occurs?

A

it depends on the method of administration as it varies in different speeds

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16
Q

What are the factors that affect drug absorption

A

Formulation
stability of drug to acid and enzymes
empty stomach/food

17
Q

how to know if the drug has been absorbed?

A

Blood level monitoring

plasma concentration

18
Q

What is the absorption phase

A

absorption rate > elimination rate

19
Q

What is postabsorption phase

A

Elimination rate > absorption rate

20
Q

What is elimination phase

A

no significant absorption occur (only the elimination process)

21
Q

What is bioavailability?

A

where a substance or drug becomes completely available to its intended biological destinations

22
Q

Factors that could affect bioavailability

A
  • route of administration
  • any drug metabolism that occurs before reaches circulation will reduce the bioavailability
  • time in GI tract
  • hydrophobicity of drug
  • Presence/absence of food
  • formulation of the drug
  • chemical reaction