Therapeutic Proteins--Fitz

Question 1

Generally, which have shorter half lives?
monoclonal antibodies
cytokines

Answer 1

cytokines

TNF–half-life is measured in minutes

Question 2

Why might a mouse antibody be more beneficial than a human antibody in some cases?

Answer 2

mouse antibodies recruit the immune system to kill cells

Question 3

A bad type III hypersensitivity reaction leads to what condition?

Answer 3

serum sickness

Question 4

Specific type of type III hypersensitivity to mouse antibodies

Answer 4

HAMA: human anti-mouse antibody response

Question 5

You want to treat someone with an immunosuppresive agent, what do you do first?

Answer 5

Mantoux: worry about reactivation of latent infection

Question 6

HTN and increased tumor growth are specific side effects of

Answer 6

EPO

Question 7

Filgrastim is an analogue of what?

Answer 7

G-CSF

Question 8

Filgrastim side effects

Answer 8

G-CSF
mild/moderate bone pain
splenic rupture

Question 9

Sagramostim is an analogue to what?

Answer 9

GM-CSF

Question 10

Sagramostim side effects

Answer 10

capillary leak syndrome
edema
moderate/severe bone pain

Question 11

MOA IL-11

Answer 11

increased platelet production

Question 12

Side effects of IL-11

Answer 12

atrial fibrillation

hypokalemia