Complement--Regal

Question 1

Which complement activation pathway requires antibodies present?

Answer 1

classical

Question 2

What is the order of activation for complement components?

Answer 2

142356789

Question 3

Which two components of the complement system can themselves bind pathogen membrane via thioester bonds?

Answer 3

C3b and C4b

Question 4

How many different forms of C3 convertase are there?

Answer 4

2

Question 5

What is the C3 convertase in the classical pathway?

Answer 5

C4b2a

Question 6

What is the C3 convertase in the MBL pathway?

Answer 6

C4b2a

Question 7

What is the C3 convertase in the alternative pathway?

Answer 7

C3bBb

Question 8

What is the C5 convertase in the alternative pathway?

Answer 8

C3bBb3b

Question 9

What is the C5 convertase in the classical pathway?

Answer 9

C4b2a3b

Question 10

What is the C5 convertase in the MBL pathway?

Answer 10

C4b2a3b

Question 11

Properdin does what?

Answer 11

stabilizes C3bBb C3 convertase

Question 12

What is the function of MASP-1 and MASP-2?

Answer 12

function with MBL to activate C4 and C2

Question 13

Which Ig is most effective at activating complement?

Answer 13

IgM–it is found in a pentemeric form, complement requires two adjacent Fc receptors to bind to opsonized organisms

Question 14

What does the alternative pathway recognize?

Answer 14

surface structures–LPS, flaggela, etc.

Question 15

What are the functions of Factor B and Factor D?

Answer 15

Factor B binds C3(H20) and Factor D cleaves C3(H20)B to C3bBb

Question 16

What is the function of S-protein?

Answer 16

deactivates the C5b-9 pore-forming complex in the serum

Question 17

High sialic acid = good/poor binding

Answer 17

poor (we have high)

Question 18

Factor H function

Answer 18

C3 convertase fluid phase inhibitor

Question 19

C1 inhibitor deficiency

Answer 19

hereditary angioedema

–complement activation like crazy

Question 20

DAF (CD55) and CD59 deficiency

Answer 20

paroxysmal nocturnal hemoglobinuria

Question 21

Anaphylotoxins

Answer 21

C3a and C5a

Question 22

Which receptor is the in for EBV?

Answer 22

CR2 (CD21)

Question 23

CR1 (complement receptor 1) binds what?

Answer 23

C3b and C4b (the ones on the membranes)