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IHO Wk 2 > Antineoplastics--Fitz > Flashcards

Antineoplastics--Fitz Flashcards

1
Q

Vincristine

  • MOA
  • CCS
  • target
  • similar drugs
A
  • inhibits microtubule formation
  • M and S phases
  • tubulin (stabilizes)
  • paclitaxel (stabilizes microtuble formation)
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2
Q

Doxorubicin

  • MOA
  • CCS
  • target
  • similar drugs
A

-intercollating agent
-CCNS
-DNA/RNA
-

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3
Q

Lenalidomide/Thalidomide

  • MOA
  • CCS
  • target
  • similar drugs
A
  • many: inhibit TNF-alpha synthesis, decrease VEGF production, others
  • CCNS
  • many
  • each other
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4
Q

Melphalan

  • MOA
  • CCS
  • target
  • similar drugs
A
  • alkylating agent
  • CCNS
  • DNA
  • cyclophosphamide
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5
Q

Cyclophosphamide

  • MOA
  • CCS
  • target
  • similar drugs
A
  • alkylating agent
  • CCNS
  • DNA
  • melphalan
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6
Q

Arabinoside

  • MOA
  • CCS
  • target
  • similar drugs
A
  • pyrimidine analog
  • S phase
  • DNA-Pol-alpha
  • 5-FU
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7
Q

Methotrexate

  • MOA
  • CCS
  • target
  • similar drugs
A

-dihydrofolate reductase antagonist
-S phase
-DHFR
-

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8
Q

6-mercaptopurine (purinethol)

  • MOA
  • CCS
  • target
  • similar drugs
A
  • purine analoge
  • S phase
  • PNP and PRPP
  • fludarabine
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9
Q

CIK therapy

  • MOA
  • CCS
  • target
  • similar drugs
A

-secretes INF-gamma in response to missing MHC-I receptors
-CCNS
-MHC-I receptors
-

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10
Q

rhIL-2

  • MOA
  • CCS
  • target
  • similar drugs
A

-induces CD4+ and NK-cell proliferation
-CCNS
-IL-2 receptor
-

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11
Q

Bortezobib

  • MOA
  • CCS
  • target
  • similar drugs
A

-inhibits proteosome in B-cell, leads to cytotoxic buildup of proteins in proliferating cells
-CCNS
-B-cell proteosome
-

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12
Q

Ifosfamide

  • MOA
  • CCS
  • target
  • similar drugs
A
  • crosslink DNA
  • CCNS
  • DNA
  • cisplatin
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13
Q

Etoposide

  • MOA
  • CCS
  • target
  • similar drugs
A

-inhibitos topo-II
-S-phase
-topo-II
-

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14
Q

Fludarabine

  • MOA
  • CCS
  • target
  • similar drugs
A
  • purine analog
  • S-phase
  • DNA-Pol
  • purinethol (6-meraptopurine)
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15
Q

Cisplatin

  • MOA
  • CCS
  • target
  • similar drugs
A
  • crosslinking agent
  • CCNS
  • DNA
  • ifosfamide
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16
Q

5-FU

  • MOA
  • CCS
  • target
  • similar drugs
A
  • pyrimidine analog
  • S-phase
  • DNA-Pol
  • arabinoside
17
Q

Paclitaxel

  • MOA
  • CCS
  • target
  • similar drugs
A
  • microtuble stabilization
  • M-phase
  • tubulin
  • vincristine (inhibits microtubule formation)
18
Q

Carmustine

  • MOA
  • CCS
  • target
  • similar drugs
A
  • alkylating agent
  • CCNS
  • DNA
  • temozolamide, busulfan, melphalan, cyclophosphamide
19
Q

Temozolamide

  • MOA
  • CCS
  • target
  • similar drugs
A
  • alkylating agent
  • CCNS
  • DNA
  • carmustine, busulfan, melphalan, cyclophosphamide
20
Q

Rituximab

  • MOA
  • CCS
  • target
  • similar drugs
A

-binds CD20 on B-cells
-CCNS
-B-cell CD20
-

IHO Wk 2 (12 decks)

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