Anemia II--Krafts Flashcards
Definitive test for hemoglobinopathies
Hb electrophoresis
What is a heterozygote of sickle cell called?
sickle cell trait
What complication does sickle cell disease relating to the spleen?
autosplenectomy
- multiple infarctions
- fibrosis
- becomes fibro-nubbin
Asplenic individuals have trouble getting rid of what type of infections?
large, encapsulated bugs
Howell-Jolly bodies are what?
remnants of RBC nucleus that remain in cells after splenectomy
What are Pappenheimer bodies?
iron buildups in RBCs after splenectomy
Where are platelets stored in normal physiology?
spleen
Asplenic individuals should be vaccinated against which two organisms?
S. pneumoniae
H. influenzae
Basic path of thalassemia
quantitative deficit in either alpha or beta change
What is the mutation in sickle cell anemia?
Val instead of Glu in beta-chain
Bite cells are due to what pathology?
partial phagocytosis of RBCs with Heinz bodies
G6PD deficiency
In which pathology are Heinz bodies seen?
G6PD deficiency
Microangiopathic hemolytic anemia shows this cell type under peripheral smear examination
schistocytes
Triangulocytes are diagnostic for what disease?
microangiopathic hemolytic anemia
What is the pathology of microangiopathic hemolytic anemia?
RBCs squeezed around fibrin thrombus balls and get all messed up
