Blood Composition--Goueli Flashcards
1
Q
How is ascites formed due to liver failure?
A
liver normally makes serum proteins (esp. albumin), in liver failure they are not made and therefore the plasma osmotic gradient isn’t large enough to draw fluid back into the vasculature from the intraperitoneal cavity, leading to fluid buildup
2
Q
Methamoglobinemia is what?
A
congenital/acquired lack of cytochrome b5 reductase activity
3
Q
What is the drug we should know that causes methamoglobinemia?
A
benzocaine
4
Q
What are the genetics of G6PD deficiency?
A
X-linked inheritance pattern
5
Q
What shifts the oxygen-Hb curve to the right?
A
decreased pH
pCO2 increase
2,3-BPG increase (from glycolysis pathway shunt)
6
Q
What is the pathology of hereditary spherocytosis?
A
defect in erythrocyte cytoskeletal component
