Theory - Schizophrenia 03

Question 1

What happens when you block the NMDA receptor?

Answer 1

You lose inhibition and the neuron does not fire in a synchronized fashion, making the GABAnergic neuron not respond correctly. This neuron inhibits dopamine normally and it goes up to the nucleus accumbens to activate D2 receptors and give positive symptoms

Question 2

Information starts in the motor cortex, goes to the stratum, to the globus pallidus, to the thalamus, and back to the cortex forming a loop. How does dopamine impact this loop?

Answer 2

It regulates the flow and this loop

Question 3

What are the positive symptoms of schizophrenia believed to arise from?

Answer 3

Hyperactivity of the mesolimbic system

Question 4

There are two different loops in the nucleus accumbens, one controls motion and the other controls emotion. What does dopamine regulate?

Answer 4

Dopamine can regulate emotion and motion

Question 5

Dopamine plays a crucial role in modulating neurotransmission within the nucleus accumbens, and the nucleus accumbens is the critical region in which both typical and atypical antipsychotics are able to attenuate the _______ symptoms of schizophrenia

Answer 5

Positive

Question 6

The blockade of which receptors in the nucleus accumbens is primarily responsible for controlling positive symptoms?

Answer 6

D2 (and D3)

Question 7

Which of the following causes in which attenuates schizophrenia?
D2
5HT-2A
D1

Answer 7

Causes:

• D2
• 5HT-2A

Attenuates:
- D1

Question 8

In schizophrenia there is too little D1 receptor-mediated neurotransmission in the PFC, how can you boost D1 receptor-mediated responses?

Answer 8

Antagonism of 5HT-2A or D2