Drugs - Dyskenesias - Tourettes Flashcards
1
Q
Basal ganglia dysfunction is part of the problem in what disease?
A
Tourette’s
2
Q
What is Tourette’s beleived to be due to?
A
An imblance of dopamine, norepinephrine, and serotonin in the CNS
3
Q
What are the manifestations of Tourette’s?
A
- Multiple motor tics
- vocalizations
- coprolalia
- head nodding
- blinking
- finger counting
- tongue protrusions
4
Q
What is there a high co-incidence of Tourette’s with?
A
OCD and ADHD
5
Q
What are the drugs used to treat Tourette’s?
A
- Haloperidol (D2 blocker most often used)
- Pimozide (D2 blocker with less sedation and lethargy)
- Clonidine (alpha-2 agonist = most effective against motor tics)
6
Q
Which other antipsychotic drug can be used in patients unresponsive or intolerant of haloperidol in the treatment of Tourette’s?
A
Pimozide
