Drugs - Parkinsons - COMT Inhibitors Flashcards by Jesus Castro | Brainscape

Q

Which are the COMT inhibitors used in Parkinson’s?

A

Tolcapone (Tasmar)

Entacapone (Comtan)

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Q

What are the method of action of the COMT inhibitors?

A

They block the peripheral conversion of levodopa to 3-O-methyldopa, allowing for increased levels of levodopa to be delivered centrally

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Q

What is the difference about where COMT is inhibited between Talcapone and Entacapone?

A

Talcapone - in the CNS and periphery

Entacapone - periphery

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Q

Which Parkinson’s agent can produce explosive diarrhea after 30 to 40 days on this drug?

A

Talcapone

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Q

Which Parkinson’s agent has the potential for serious hepatotoxicity and thus requires informed consent before use?

A

Talcapone

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