Drugs - Antipsychotic - Typical 03

Question 1

Which are the Butyrophenone typical antipsychotic agents?

Answer 1

Haloperidol (Haldol)

Droperidol

Question 2

What is the MOA of Haloperidol?

Answer 2

Very potent D2 and weak alpha-1 blocker (but minimal or no anticholinergic effects), alleged to have anti-agitation properties for use in hostile emergencies

Question 3

Which formulation of haloperidol has been associated with tsoardes and subsequent ventricular arrhythmias?

Answer 3

IV (not oral or IM)

Question 4

Which is the most potent typical anti-psychotic agent?

Answer 4

Haloperidol (along with fluphenazine)

Question 5

What are the side effects of haloperidol?

Answer 5

High incidence of EPS (since EPS follows potency)

Question 6

Which antipsychotic is used when changing burn dressings or for endoscopy?

Answer 6

Droperidol. It produces a neurolept analgesia (dissociative analgesia) but the patient is responsive to commands.

Question 7

What is the combination of Droperidol with Fentanyl?

Answer 7

Innovar. Fentanyl is a potent narcotic analgesic (pain killer)

Question 8

Which are the Dibenzoxazepine typical antipsychotics?

Answer 8

Loxapine

Question 9

What is the potency of Loxapine?

Answer 9

Intermediate thus intermediate EPS

Question 10

What is odd about the “typical” profile of Loxapine?

Answer 10

It is considered typical despite the fact that 5HT2A receptor affinity > D2 receptor affinity

Question 11

Which are the Dihydroindolone typical antipsychotics?

Answer 11

Molindone

Question 12

What are the benefits of Molindone?

Answer 12

Little or no weight gain and less likely to lower the seizure threshold so less seizures

Question 13

What is the potency of Molindone?

Answer 13

Intermediate to high potency and EPS