The Nucleus Flashcards
4 main functions of the nucleus
stores genomic DNA
replicates the genomic DNA once every cell cycle
expresses genes at the right time in the right cell type
communicates with cytoplasm
why do we care about the nucleus
increasing evidence that the structure of nucleus and interactions between sub-nuclear domains are vital for correct and efficient gene expression
what are 4 important features of the nucleus
chromosomes
the nucleolus
nuclear speckles
nuclear bodies
two points about chromosomes
not tangles but discrete territories
different levels of chromatin condensation in a human nucleus
what is the nucleolus
makes ribosomes
what is the structure of the nucleolus
fibrillar centre site of genes encoding ribosomal rna and dense fibrillar site of rrna processing
what are nuclear speckles
most likely storage sites for splicing factors and well characterised, specific and dynamic
what are nuclear bodies
a variety of structures
why are nuclear bodies termed that`
because tend to be spherical
what are 4 examples of nuclear bodies and their functions
PML-transcription regulation
cleavage-formation of 3’ end of mRNA
cajal and gems- synthesis of snRNP splicing factors
