signalling in development and differentiation Flashcards
what are urochordates
sister group to vertebrates
what are three models for lineages
sagittal
para sagittal
cross section(tail)
what are fate maps developed from
cell embryos
what is the linking concept
lineages and fate
all descendents of the a6.6 lineage will have a trunk epidermis fate
what is a combinatorial code
cell identity can be defined by combinations of expressions of TFs and ligands
what are three ways to develop different tissue
boundaries and compartment formation
adhesion and signalling
linking development and stem cells
what is possible between cell adhesion molecules
heterophilic and homophilic interactions
what is cell sorting caused by
differential adhesion
when is beta catenin multifunctional
cell-cell adhesion
wnt signalling
how are devempment and stem cells linked
early embryps are effectively totipotent stem cells
adults used resident lineage restricted stem cells for cell renewal and regeneration
stem cells are affected by niche microenvironmenr
human diseases and aging directly related to stem cell misregulation
its all about regulatinf differentiation and cell fate choice
three points about stem cells
ability to self renew
capable of differentiation
themselves undiffernetiated
what are the three types of potencies
plur/totipotent- make all cells
multipotent- can make many cell types
lineage restriction- can make one cell type
what is hematopoiesis
a heirarchical process
what is the intestinal crypt
differentiated cell types of small intestines
what complex signal mediates intestinal differentiation
eph/ephrin
