The Endocrine Pancreas - Disruption of the Steady State

Question 1

true/false exercising increases glucose uptake into skeletal muscle without insulin

Answer 1

true - in active muscle GLUT-4 transporters can be moved to cell membrane without insulin trigger

Question 2

true/false exercise reduces the sensitivity of tissue to insulin

Answer 2

false - number of GLUT-4 transporters in membrane increases and lasts for several hours

Question 3

true/false regular exercise can produce prolonged increases in insulin sensitivity

Answer 3

true

Question 4

how does the brain change following periods of starvation

Answer 4

it adapts to be able to use ketones

Question 5

ketone formation from TAG stores in fat

Answer 5

TAG –> free fatty acids –> ketones

Question 6

why is protein one of the last stores to be broken down for energy

Answer 6

because losing protein leaves us vulnerable and weak

Question 7

ketones are acidic/alkaline

Answer 7

acidic

Question 8

why does plasma ketone build up in DMt1

Answer 8

lack of insulin –> less ketone body uptake

Question 9

what result of high ketones in plasma makes it a deadly situation

Answer 9

the acidosis it produces