The Blood Flashcards

1
Q

define Hematocrit (Hct)

A

ratio of volume of formed elements/total blood volume

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2
Q

what is the most abundant blood protein?

A

Serum Albumin (~50%)

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3
Q

where is albumin synthesized?

A

Liver

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4
Q

what is the role of Albumin?

A
  1. transport hormones, free fatty acids, drugs, bilirubin
  2. creates colloid osmotic/oncotic pressure
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5
Q

what disease is albumin associated with?

A
  1. kidney disease
  2. liver disease
  3. malnutrition
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6
Q

relationship between Hct and O2?

A

the greater the Hct the greater the O2 carrying capacity of the blood

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7
Q

Clinical implications of Hct

A

as Hct declines, so must exercise level

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8
Q

Hct and hemoglobin relationship

A

as hematocrit goes down, so does hemoglobin levels

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9
Q

what are the fluid parts of the blood?

A
  1. plasma
  2. serum
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10
Q

what is plasma?

A

liquid component of blood, contains:

  1. water
  2. electrolytes
  3. clotting factors
  4. proteins
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11
Q

what is the main difference between plasma and serum?

A

serum lacks clotting factors

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12
Q

what is oncotic pressure?

A

defined by presence of the concentration of plasma proteins. Causes water to move back into the circulatory system

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13
Q

Name 7 types of blood cells

A
  1. neutrophils
  2. eosinophils
  3. basophils
  4. lymphocytes
  5. monocytes
  6. platelets
  7. erythrocytes
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14
Q

T/F: RBC have both nuclei and mitochondria

A

FALSE

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15
Q

the majority of WBCs are _____

A

Neutrophils (which are phagocytic)

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16
Q

neutrophils account for ________

A

50-70% of WBC

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17
Q

what is thrombocytopenia?

A

deficiency of platelets

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18
Q

what are the 3 stages of blood clot formation?

A
  1. platelets attach to endothelium
  2. platelets start to relase fibrin and bring to seal the endothelium
  3. the fibrin network traps RBCs and completely seal the endothelium
19
Q

what is the function of eosinophils?

A
  1. help detoxify foreign substance
  2. secrete enzymes that dissolve clots
  3. fights parasitic infections
20
Q

what is the function of basophils?

A

release anticoagulant/heparin

21
Q

what clot repressing molecules are released to prevent clot formation?

A
  1. Prostacyclin PGI2
  2. NO
  3. CD 39: enzyme that breaks down ADP
22
Q

what is VWF?

A

Von Willegrand’s factor

23
Q

what does VWF do?

A

binds platelets to exposed collagen.

24
Q

What is Virchow’s Triangle?

A

factors that ID increased risk for an embolism

25
Q

what are the 3 components of Virchow’s Triangle?

A
  1. stasis of blood flow
  2. endothelial injury
  3. hypercoagulability
26
Q

name a population you would be concerned about with stasis of blood flow.

A

Patients on bed rest, people with sedentary lifestyles

27
Q

define hemostasis

A

stoppage of bleeding

28
Q

what is the normal hematocrit level for women?

A

36-46%

29
Q

What is the normal hematocrit level for men?

A

41-53%

30
Q

normal values for WBCs?

A

5000-10000

31
Q

normal RBC count?

A

4 million - 6 million

32
Q

normal hemoglobin in women?

A

12-14 g/dL

33
Q

normal hemoglobin in men

A

11-15 g/dL

34
Q

what is considered a normal MAP?

A

65-110 mmHg

35
Q

what does an ANC <500 mean?

A

dramatic infection

36
Q

Type A have ______ antigen and ______antibody

A

A antigen

anti-B antibody

37
Q

what is a granulocyte?

A

a leukocyte that has a mitochondria and nuclei

38
Q

T/F: granulocytes make up the majority of WBCs?

A

TRUE

39
Q

what WBCs are granulocytes?

A
  1. Neutrophils
  2. Basophils
  3. Eosinophils
40
Q

what are monocytes?

A

WBCs that have an absence of granules in the cytoplasm

41
Q

what WBCs are agranulocytes?

A
  1. Monocytes
  2. Lymphocytes
42
Q

T/F: Atrial Fibrillation can cause stasis of blood flow

A

TRUE

43
Q

what is hematopoiesis?

A

blood cell formation (it occurs in bone marrow)