Skeletal Muscle Wrap Up Flashcards
what are satellite cells?
small mononuclear progenitor cells with virtually no cytoplasm
what do satellite cells do?
go through proliferation and maturation and replace damaged muscle cells with healthy muscle cells
what often constrains the the regenerative capacity of injured skeletal muscle?
formation of fibrotic tissue
how do satellite cells replace damaged muscle cells?
they divide and fuse together between injury site and then mature into a fully-fledged myocyte
what happens to the # of satellite cells as we age?
decreases
define sarcopenia
age associated loss of muscle mass
can sarcopenia be prevented?
Yes, through weight/strength training
T/F: sarcopenia patients have less satellite cells
TRUE
describe the general events during skeletal muscle repair
injury → increased VD &, vascular permeability, and increased WBC’s → stimulates satellite cell proliferation → satellite cells mature into skeletal myoblasts → differentiate into adult muscle cells
what role do Fibroblasts play in skeletal muscle repair?
assist in producing connective tissue scar after satellite cells arrive and fill the injury space
Name 3 physiological changes to muscle tissue that occur with age
- Sarcopenia
- Reduced capillary blood supply
- fewer satellite cells
define cachexia
muscle wasting and is associated with increased levels of cytokines, inflammatory markers and tumor products. It is an Autonomic dysfunction
where is smooth muscle found?
- Blood vessel walls
- bronchioles
- digestive organs
- urinary and reproductive tracts
