tetracyclines and glycylcyclines

Question 1

resistance

not affected by the 2 major tetracycline resistance mechanisms: efflux pumps and ribosomal protection

Answer 1

tigecycline

Question 2

resistance

retains susceptibility, even given the cross resistances observed among tetracycline antibiotics

Answer 2

minocycline

Question 3

spectrum of activity of tetracyclines/glycylcyclines

Answer 3

G+ and G- aerobic bacteria and unusual bacteria

Question 4

active tetracyclines against G+ aerobes

Answer 4

minocycline and doxycycline

Question 5

active against a broad range of G+ and G- aerobic and anaerobic bacteria, including some tetracycline resistant strains

Answer 5

tigecycline

Question 6

tigecycline is NOT active against…

Answer 6

proteus mirabilis and pseudomonas aeruginosa

Question 7

IV use against rocky mountain spotted fever?

Answer 7

doxycycline

Question 8

which is available IV, PO, or both?

Answer 8

tigecycline: IV only
doxycycline: both
tetracycline: PO only
minocycline: PO only

Question 9

elimination

which drugs need dosage adjustments for renal insufficiency?

Answer 9

none

Question 10

elimination

which drug need dosage adjustments for hepatic impairment?

Answer 10

tigecycline

Question 11

clinical uses

main use for tetracyclines?

Answer 11

treatment of infections due to unusual organisms

Question 12

GREAT drug to use for CA pneumonia

Answer 12

doxycycline

Question 13

drug to use for rickettsial infections

Answer 13

doxycycline or tetracycline

Question 14

drug to use for chlamydial infections

Answer 14

doxycycline

Question 15

drug to use for nongonococcal urethritis

Answer 15

doxycycline

Question 16

drug to use for brucellosis

Answer 16

doxycycline

Question 17

drug to use for bartonellosis

Answer 17

doxycycline

Question 18

drug to use for acne

Answer 18

minocycline

Question 19

drug to use for the plague

Answer 19

doxycycline

Question 20

drug to use for clostridial infections

Answer 20

doxycycline

Question 21

drug to use for anthrax

Answer 21

doxycycline

Question 22

drug NOT to use for peudomonas or proteus infections

Answer 22

tigecycline

Question 23

drug to use for polymicrobial infections

Answer 23

tigecycline

Question 24

don’t need to worry about dermatologic adverse effects with…

Answer 24

minocycline and tigecycline

Question 25

associated with fanconi like syndrome with outdated (this drug)

Answer 25

tetracycline

Question 26

tetracyclines are pregnancy category D because they cause…

Answer 26

permanent tooth discoloration

decrease bone growth