metronidazole

Question 1

MOA metronidazole

Answer 1

ultimately inhibits DNA synthesis

Question 2

role of ferrodoxins in metronidazole MOA

Answer 2

ferrodoxins are proteins that donate electrons to metronidazole, forming a reactive compound that damages DNA and inhibits its synthesis

Question 3

why does metronidazole have selective activity in microaerophilic/anaerobic environments?

Answer 3

because metronidazole competes with oxygen for electrons from ferrodoxins, rendering those electrons ineffective at damaging DNA

Question 4

concentration or time dependent?

Answer 4

concentration

Question 5

bacteriostatic or bactericidal?

Answer 5

bactericidal

Question 6

MOR metronidazole

Answer 6

altered growth requirements

altered ferrodoxin levels

Question 7

spectrum of activity metronidazole

Answer 7

anaerobic bacteria

bacteriodes and clostridium

Question 8

penetrate the CSF?

Answer 8

yes

Question 9

removed during hemodialysis?

Answer 9

yes

Question 10

clinical uses metronidazole

Answer 10

anaerobic infections
trichomas
H. pylori infections

Question 11

DRUG OF CHOICE FOR…

Answer 11

mild to moderate C. difficile infections (give it orally because, this way, it achieves higher concentrations in the colon)

Question 12

common adverse effects

Answer 12

CNS (peripheral neuropathy and seizures)
contraindicated in preexisting CNS disorders
mutagenicity (avoid use during pregnancy)

Question 13

important drug interactions

Answer 13

warfarin = enhanced effects
ethanol = dislufram reaction