sulfonamides

Question 1

MOA sulfamethoxazole

Answer 1

inhibit dihydrofolate formation in bacteria

Question 2

MOA trimethoprim

Answer 2

prevent tetrahydrofolate formation in bacteria

Question 3

MOA bactrim

Answer 3

inhibition in the synthesis of folate

Question 4

bacteriostatic or bactericidal

Answer 4

bactericidal

Question 5

G+ aerobes spectrum of activity

Answer 5

MRSA (especially CA MRSA)

Question 6

G- aerobes spectrum of activity

Answer 6

stenotrophomonas maltophilia (drug of choice)

Question 7

bactrim NOT active against

Answer 7

pseudomonas aeruginosa

Question 8

does bactram get into CSF?

Answer 8

yes, especially with inflamed meninges

Question 9

adjustment with impaired renal clearance?

Answer 9

yes

Question 10

THE drug of choice for 2 bugs, they are…

Answer 10

pneumocystis carinii/jiroveci (pneumonia) and stenotrophomonas maltophilia infections

Question 11

other clinical uses…

Answer 11

acute, chronic, recurrent UTIs
acute, chronic bacterial prostatitis
SSSIs due to CA MRSA

Question 12

major hematologic adverse effects and consequence?

Answer 12

leukopenia and thrombocytopenia (severe bone marrow cell suppression)
cant give this drug to AIDS patients

Question 13

adjust dose with kidney dysfunction?

Answer 13

yes

Question 14

major drug interaction with…

Answer 14

warfarin, displaces it from proteins in circulation and increases its effects