Seratonin and dopamine

Question 1

busprione

Answer 1

5HT-1A partial agonist used to treat anxiety disorders, can cause drowsiness, initial depression

Question 2

sumatriptan

Answer 2

5HT-1D agonist used in treating migraines by causing cerebral vasoconstriction and an inhibition in the release of inflammatory mediators

Question 3

fluoxetine

Answer 3

SSRI that increases the amount of serotonin in the synaptic cleft
functions to increase mood/used in depression
takes a couple of weeks to work because it non selectively binds its own 5HT-1A receptors, resulting in negative feedback which desensitizes over time

Question 4

sertraline

Answer 4

SSRI that increases the amount of serotonin in the synaptic cleft
functions to increase mood/used in depression
takes a couple of weeks to work because it non selectively binds its own 5HT-1A receptors, resulting in negative feedback which desensitizes over time

Question 5

trazadone

Answer 5

Seratonin antagonist-reuptake inhibitor
5HT-2C/2D antagonist that has anti-anxiety effects of sertraline without its increased alertness and erectile dysfunction effects
also has reuptake inhibitor capabilities of sertraline

Question 6

risperidone

Answer 6

5HT-2A/D antagonist that lowers dopamine release in the mesolimbic pathway but increases dopamine release in the mesocortical pathway used in schizophrenia and psychosis

Question 7

ondansetron

Answer 7

5HT-3 antagonist responsible for inhibiting chemo induced nausea
blocks the activity of these receptors in the gut, leading to their decreased relay of nausea information to the brain

Question 8

mosapride

Answer 8

5TH-4 agonist to promote GI peristalsis

not used due to contraindication of long QT syndrome leading to fatal arrhythmias

Question 9

cisapride

Answer 9

5HT-4 agonist to promote GI peristalsis

not used due to contraindications long QT syndrome resulting in fatal arrhythmias

Question 10

LDOPA

Answer 10

precursor to dopamine
given to Parkinson’s patients…it can cross BBB, dopamine cannot
can cause arrhythmia and dyskinesia

Question 11

carbidopa

Answer 11

an AADC (LDOPA converting enzyme) inhibitor that inhibits dopamine synthesis
useful because dopamine is rapidly degraded in the body and cannot cross the BBB
given with LDOPA in treating Parkinson's

Question 12

bromocriptine

Answer 12

dopamine receptor agonist in the basal ganglia used in treating Parkinson’s

Question 13

selegiline

Answer 13

selective MOA-B antagonist (can inhibit MOA-A at higher doses) used in Parkinson’s

Question 14

tolcapone

Answer 14

COMT antagonist that enhances the effects of LDOPA used in Parkinson’s but can cause liver failure

Question 15

haloperidol

Answer 15

D2 antagonist used in schizophrenic and psychosis patients

Question 16

methylphenidate

Answer 16

dopamine reuptake inhibitor

Question 17

metaclopramide

Answer 17

D2 antagonist and 5HT-4 agonist used for chemo induced nausea