Opioids

Question 1

bradykinin

Answer 1

excitatory neurotransmitter that stimulates the release of prostaglandins and substance P in response to tissue damage

Question 2

morphine

Answer 2

strong opioid analgesic used to relieve severe pain

Question 3

meperidine

Answer 3

strong opioid analgesic used to relieve moderate/severe pain

Question 4

norepthidine

Answer 4

meperidine metabolic product that causes side effects: serotonin syndrome, fever, dysphoria

Question 5

hyrdrocodone

Answer 5

moderate opioid analgesic that is similar to morphine but weaker
used to treat moderate pain
important in cough suppression
acts at mu and delta receptors

Question 6

mechanism of action of mu opioid receptor

Answer 6

inhibits GABA release from presynaptic nn

Question 7

codeine

Answer 7

opioid analgesic used to relieve mild/moderate pain, cough, diarrhea, IBS, narcolepsy

Question 8

pentazocine

Answer 8

opioid receptor agonist/antagonist

kappa and delta receptor agonist (useful in dental extractions), mu receptor antagonist (morphine/meperidine antagonist)

Question 9

naloxone

Answer 9

opioid receptor antagonist

completely antagonizes any effect that a mu, kappa, or delta opioid receptor agonist may have

Question 10

methadone

Answer 10

mu opioid receptor agonist that has effects very similar to morphine
is used for withdrawal from opioid addiction but may, itself, cause dependence