Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Clinical Pharmacology > Testable CYP First Exam > Flashcards

Testable CYP First Exam Flashcards

1
Q

Fluoxetine

A 
Substrate of 2D6 --> norfluoxetine
Inhibits 2D6 (strong) and 2C19 (moderate)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Paroxetine

A

Substrate 2D6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Sertraline

A

Inhibits 2D6 (moderate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Citalopram/Escitalopram

A

Substrate of 2C19 and 3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Venlafaxine

A

Substrate of 2D6 and 3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Desvenlafaxine

A

None

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Duloxetine

A

Substrate of 1A2 and 2D6

Inhibitor of 2D6 (moderate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Bupropion

A

Inhibitor of 2D6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Mirtazapine

A

Substrate of 1A2, 2D6, 3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Trazadone

A

Substrate of 3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Amitriptyline to nortriptyline via?

A

2D6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Imipramine to desipramine via?

A

2D6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

TCAs

A

Substrate of 2D6 and 2C19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Buspirone

A

Substrate of 3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

BZDs except Lorazepam

A

Substrate of 3A4 (coadmin with 3A4 inhibitors is CI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

1st gen antipsychotics

A

Substrate of 2D6 +/- 3A4

Mod inhibitor of 2D6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Atypicals

A

Above your paygrade bucko

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Melatonin receptor agonists

A

Substrates of 1A2 and 3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Atomoxetine

A

Substrate of 2D6 (major)

20
Q

Celecoxib

A

Substrate of 2C9

21
Q

Codeine –> morphine via?

A

2D6

22
Q

Hydrocodone –> hydromorphone via?

A

2D6

23
Q

Oxycodone –> oxymorphone via?

A

2D6

24
Q

Tramadol –> active metabolite via?

A

2D6

25
Q

BBW for oxycodone about interactions with? BOLD

A

3A4 inhibitors

26
Q

Fentanyl

A

3A4 major

27
Q

Hydrocodone and oxycodone

A

3A4 (major) and 2D6 (minor)

28
Q

Tramadol (prodrug)

A

3A4 and 2D6 (major)

29
Q

Codeine (prodrug)

A

2D6 (major)

30
Q

NO CYP metab with opioids

A

Morphine, Hydromorphone, Oxymorphone

31
Q

Dihydroergotamine

A

3A4 substrate

32
Q

Almotriptan & Eletriptan

A

3A4 substrate

33
Q

Sumatriptan, Rizatriptan, Zolmitriptan

A

Metabolized by MOA enzymes

34
Q

Gepants

A

3A4, PgP substrates

35
Q

Dementia Meds

A

all “fairly clean”

no cyp concerns for us

36
Q

Carbamazepine

A

3A4 substrate (major)

Induces (strong) 2C9 and 3A4 - autoinduction**

37
Q

Phenytoin

A

2C9 substrate

Induces (potently) 2C9 & 3A4 - autoinduction**

38
Q

Lamotrigine

A

Does not induce or inhibit CYP enzymes

** VPA INC [lamotrigine] > 2x **

39
Q

Lacosamide

A

Interactions: concomitant PR-prolonging drugs (b-blockers, CCBs) **

40
Q

Rufinamide

A

Interactions: drugs that SHORTEN QT interval **

41
Q

Ezogabine

A

Interactions: concomitant QT prolongers **

42
Q

Gabapentin

A

Not metabolized *

43
Q

Phenobarbital

A

Induces 2C9, 3A4 - autoinducer **

44
Q

Tiagabine

A

3A4 substrate

45
Q

Felbamate

A

3A4 substrate

46
Q

Brivaracetam

A

2C19 substrate

47
Q

Levodopa

A

MOA inhibitors block levo metabolism

Clinical Pharmacology (54 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions