$$ AED Categories $$

Question 1

“Old” 1st Gen AED

Answer 1

• phenobarbital
• phenytoin
• carbamazepine
• valproate
• ethosuximide

Question 2

“New” 2nd Gen AED

Answer 2

• gabapentin
• pregabalin
• levetiracetam/brivaracetam
• lamotrigine
• oxcarbazepine/eslicarbazepine
• tiagabine
• topiramate
• zonisamide
• felbamate
• lacosamide
• rufinamide
• ezogabine
• vigabatrin
• perampanel
• BZDs (clobazam/clonazepam)
• cannabidiol

Question 3

Partial, including secondarily generalized seizures

Answer 3

Carbamazepine
Lamotrigine
Levetiracetam
Oxcarbazepine

Question 4

Primary generalized tonic-clonic seizures

Answer 4

Lamotrigine
Levetiracetam
Valproate

Question 5

Absence Seizures

Answer 5

Ethosuximide

Valproate

Question 6

Atypical Absence, Myoclonic, Atonic Seizures

Answer 6

Lamotrigine
Levetiracetam
Valproate

Question 7

Drugs that affect Na channels

Answer 7

• carbamazepine
• oxcarbazepine/eslicarbazepine
• phenytoin/fosphenytoin
• lamotrigine
• lacosamide
• zonisamide
• rufinamide

Question 8

Drugs that affect K channels

Answer 8

• ezogabine

Question 9

Drugs that affect Ca2+ channels

Answer 9

• ethosuximide
• gabapentin
• pregabalin

Question 10

Drugs that affect GABA activity

Answer 10

• phenobarbital
• clobazam
• clonazepam
• tiagabine
• vigabatrin

Question 11

Glutamate Receptor Antagonists

Answer 11

• perampanel

Question 12

Drugs w/multiple mechanisms of action

Answer 12

• valproate

- topiramate

Question 13

Drugs w/unknown mechanism of action

Answer 13

• felbamate
• levetiracetam
• brivaracetam
• cannabidiol

Question 14

AED that make absence or myoclonic seizures worse

Answer 14

1. carbamazepine
2. oxcarbazepine / eslicarbazepine
3. gabapentin

Question 15

AED for LGS

Answer 15

1. lamotrigine
2. rufinamide
3. clobazam
4. clonazepam
5. felbamate
6. cannabidiol
7. topiramate

Question 16

AED requiring ECG rhythm monitoring

Answer 16

1. IV phenytoin / fosphenytoin
2. lacosamide
3. rufinamide
4. ezogabine

Question 17

AED and bicarb monitoring and oligohidrosis

Answer 17

1. zonisamide

2. topiramate

Question 18

AED associated with euphoria; scheduled list

Answer 18

1. lacosamide
2. ezogabine
3. pregabalin
4. perampanel
5. brivaracetam
6. cannabidiol
7. BZDs

Question 19

AED Teratogens

Answer 19

** VPA **

Other:

• topiramate
• phenytoin
• carbamazepine
• lamotrigine
• phenobarbital

Question 20

AED with psychiatric concerns

Answer 20

1. levetiracetam
2. brivaracetam
3. ethosuximide
4. perampanel (homicide)
5. ezogabine

Question 21

AED associated with SJS

Answer 21

1. carbamazepine
2. lamotrigine
3. zonisamide
4. Phenytoin

Question 22

AEDs indicated for Post herpetic neuralgia or Trigeminal neuralgia

Answer 22

1. carbamazepine (trigeminal neuralgia)
2. gabapentin
3. pregabalin

Question 23

AEDs indicated for manic/bipolar

Answer 23

1. carbamazepine
2. oxcarbazepine / eslicarbazepine
3. lamotrigine
4. valproate

Question 24

AEDs indicated for Restless leg syndrome

Answer 24

1. gabapentin

2. pregabalin

Question 25

AEDs that do autoinduction; must monitor concentration levels

Answer 25

1. carbamazepine
2. phenytoin / fosphenytoin
3. phenobarbital

Question 26

AEDs causing SIADH (hyponatremia)

Answer 26

1. carbamazepine

2. oxcarbazepine / eslicarbazepine

Question 27

AED causing retinal toxicity

Answer 27

vigabatrin

Question 28

AEDs w/concern for hepatotoxicity

Answer 28

1. valproate*

2. phenytoin / fosphenytoin

Question 29

AEDs indicated for migraine prophylaxis

Answer 29

1. valproate (cat X if pregnant)

2. topiramate

Question 30

AEDs used for prevention of early seizures following TBI/NS

Answer 30

1. levetiracetam

2. phenytoin