Drug MOA (Semester List)

Question 1

SSRI

Answer 1

Block presynaptic 5-HT reuptake pump –> INC synaptic 5-HT

Question 2

SNRI

Answer 2

Psych: inhibitor 5-HT & NE

Pain mgmt: unknown

Question 3

SSRI & Partial 5-HT1A Rec AG

Answer 3

Inhibit serotonin reuptake & AG of 5-HT1A rec

Question 4

Bupropion

Answer 4

MOA not fully understood, somewhat stimulating

Blocks NE & DA uptake

Question 5

Trazadone

Answer 5

1. AAG at 5-HT2A & 2C rec (hypnotic effect?)
2. SSRI
3. AAG at H1 (sedation) and a1 rec (postural hypoTN)

Question 6

Mirtazapine

Answer 6

1. AAG of central pre/post synaptic a2 rec (INC NE) & 5HT2/3 (INC serotonin)
2. Potent H1 rec AAG (sedation)

Question 7

TCA - Tertiary Amines

Answer 7

SSRI-like: INC synaptic serotonin concentration +/- NE in CNS by inhibiting reuptake

Other:

1. a1 (orthostasis)
2. histaminic (sedation, wt gain)
3. muscarinic (anticholinergic)

Question 8

TCA - Secondary Amines

Answer 8

More SNRI-like: INC synaptic NE in CNS by inhibiting reuptake

Hits same receptors as tertiary amines (a, h, m) but less interaction

Question 9

MOAI-A

Answer 9

INC all endogenous (NE, DA, 5-HT) through inhibition of MAO

Question 10

MOAI-B

Answer 10

DA

Question 11

Barbiturates

Answer 11

Modulate GABA system

Question 12

BZD

Answer 12

Bind BZD receptor on post-synaptic GABA neuron –> potentiates endogenous GABA (main inhibitory NT)

Shift in Cl- ions results in hyperpolarization & stabilization

Question 13

Lithium

Answer 13

Uncertain MOA

Alters cation transport across cell membrane in nerves, muscle cells.

Influences reuptake of 5-HT +/- NE

Question 14

1st Gen Antipsychotics

Answer 14

AAG of postsynaptic mesolimbic DA receptors

AAG of:

• alpha (orthostasis)
• histaminic (sedation, wt gain)
• muscarinic (anticholinergic)

Question 15

2nd Gen Antipsychotics

Answer 15

Additional AAG

• alpha
• histaminic
• muscarinic

Question 16

2nd Gen Antipsychotics

AAG of 5HT2 & D4

Answer 16

Clozapine

Question 17

2nd Gen Antipsychotics

AAG of 5HT2

Answer 17

Risperidone
Olanzapine
Quetiapine
Ziprasidone 
Paliperidone
Asenapine
Iloperidone
Lurasidone

Question 18

2nd Gen Antipsychotics

Partial AG at D2 & 5HT1A
and
AAG 5HT2A

Answer 18

Aripiprazole
Brexpiprazole
Cariprazine

Question 19

1st Gen Antihistamine

Answer 19

Anticholinergic

Question 20

NBRAs

Answer 20

AG on GABA-A rec complexes (close to or coupled w/BZD1 rec)

Minimal AG of BZD2 receptor = minimal anxiolytic, myorelaxant, anticonvulsant properties

Question 21

Melatonin Receptor AG

Answer 21

Selective AG of melatonin rec MT1 > MT2 w/in suprachiasmatic nucleus of hypothalamus

M1: induce sleepiness
M2: influences regulation of sleep-wake cycle

Question 22

Orexin Rec AAG

Answer 22

Block orexin neuropeptides from binding to their receptors - prevents “wakefulness”

Question 23

Stimulants (ADHD)

Answer 23

INC NE, DA in BS, midbrain, frontal cortex

Question 24

Methylphenidate

Answer 24

Block reuptake of NE/DA into presynaptic neurons in CNS - INC concentration in synapse

Question 25

Amphetamine

Answer 25

Promote release of NE/DA from vesicles in presynaptic nerve terminals

Question 26

Atomoxetine

Answer 26

SNRI

Question 27

Guanfacine

Answer 27

Selective a2A AG

Question 28

Clonidine

Answer 28

NON-selective a2A, B, C, and imidazoline rec AG [non-selective alpha modulator]