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Clinical Pharmacology > Drug Metabolism Flipped > Flashcards

Drug Metabolism Flipped Flashcards

1
Q

ADs: fluoxetine, sertraline, duloxetine, paroxetine, bupropion

A

2D6 inhibitor

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2
Q

Amiodarone

A

inhibits: 1A2, 2C8/9, 2D6, 3A4, Pgp
substrate: 3A4, Pgp

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3
Q

Apixaban/rivaroxaban

A

3A4 substrate

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4
Q

Atorvastatin/simvastatin

A

substrate: 3A4, Pgp

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5
Q

Atypical antipsychotics (aripiprazole, risperidone)

A

substrate: 2D6, 3A4

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6
Q

BZDs

A

substrate: 3A4

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7
Q

Carbamazepine

A

substrate: 3A4

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8
Q

Carbamazepine/phenytoin

A

inducer: 1A2, 2C8/9, 2C19, 3A4, Pgp
substrate: Pgp

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9
Q

Carvedilol

A

substrate: 2C8/9
inhibitor: Pgp

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10
Q

CCBs (amlodipine, verapamil, diltiazem)

A

substrate: 3A4

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11
Q

Cimetidine

A

inhibitor: 1A2, 2C19, 2D6, 3A4

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12
Q

Ciprofloxacin

A

inhibitor: 1A2

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13
Q

Citalopram

A

substrate: 2C19

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14
Q

Clarithromycin

A

substrate: 3A4
inhibitor: 3A4, Pgp

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15
Q

Clopidogrel

A

substrate: 2C19
inhibitor: 2C8/9

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16
Q

Codeine

A

substrate: 2D6

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17
Q

Cyclosporine, tacrolimus, siroliumus

A

substrate: 3A4

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18
Q

Dabigatran/rivaroxaban

A

substrate: Pgp

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19
Q

Dexamethasone

A

inducer: Pgp

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20
Q

Digoxin

A

substrate: Pgp

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21
Q

Diltiazem

A

substrate: Pgp

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22
Q

Diltiazem/verapamil

A

inhibitor: 3A4, Pgp

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23
Q

Duloxetine

A

substrate: 1A2

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24
Q

Estrogen

A

substrate: 3A4, Pgp
inhibitor: 1A2

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25
Q

Fluconazole

A

inhibitor: 2C8/9, 2C19, 3A4

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26
Q

Fluoxetine

A

inhibitor: 2C19

27
Q

Fluoxetine, paroxetine, duloxetine

A

substrate: 2D6

28
Q

Gemfibrozil

A

inhibitor: 2C19

29
Q

Gemfibrozil/fenofibrate

A

inhibitor: 2C8/9

30
Q

Grapefruit Juice

A

inhibitor: 3A4

31
Q

Many chemo

A

substrate: Pgp

32
Q

Metoprolol

A

substrate: 2D6

33
Q

Metronidazole

A

inhibitor: 2C8/9

34
Q

Most PPI (omeprazole)

A

substrate: 2C19

35
Q

Non DHP CCBs (verapamil, diltiazem)

A

inhibitor: 3A4

36
Q

OCPs

A

substrate: 3A4

37
Q

Omeprazole

A

substrate: Pgp

38
Q

Omeprazole/esomeprazole

A

inhibitor: 2C19

39
Q

Opioids (hydrocodone, oxycodone)

A

substrate: 3A4

40
Q

Paroxetine/sertraline

A

substrate: Pgp

41
Q

PDE5 inhibitors (sildenafil, tadalafil, vardenafil)

A

substrate: 3A4

42
Q

Phenytoin

A

substrate: 2C8/9, 2C19

43
Q

Pioglitazone

A

substrate: 2C8/9

44
Q

PIs (ritonavir)

A

3A4 substrate, inhibitor

45
Q

Rifampin

A

inducer: 1A2, 2C8/9, 2C19, 3A4, Pgp

46
Q

Smoking

A

inducer: 1A2

47
Q

SSRI (citalopram, paroxetine, sertraline)

A

substrate: 3A4

48
Q

St. Johns Wort

A

inducer: 2C8/9, 2C19, 3A4, Pgp

49
Q

TCAs

A

substrate: 1A2, 2C8/9, 2C19, 2D6

50
Q

THC

A

inducer: 1A2

51
Q

Theophylline

A

substrate: 1A2, 3A4

52
Q

TMP-SMX

A

inhibitor: 2C8/9

53
Q

Valproate

A

inhibitor: 2C8/9

54
Q

Warfarin

A

substrate: 2C8/9

55
Q

Mirtazepine

A

substrate: 1A2, 2D6, 3A4

56
Q

Melatonin Receptor Agonist

A

substrate: 1A2, 3A4

57
Q

Conventional Antipsychotics (chlorpromazine, haloperidol)

A

2D6 substrate/inhibitor; 3A4 substrate

58
Q

Atomoxetine

A

2D6 substrate

59
Q

Buspirone

A

3A4 substrate

60
Q

Venlafaxine

A

2D6, 3A4 substrate

61
Q

Trazodone

A

3A4 substrate, Pgp inducer

62
Q

NBRA (zolpidem, eszopiclone)

A

3A4 substrate

63
Q

Celecoxib

A

2C9 substrate

Clinical Pharmacology (54 decks)

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