test 8 Total artificial heart history

Question 1

1958

Answer 1

 Total artificial heart was used in a dog model

 Supported for 90 min.

Question 2

1962

Answer 2

 Reporting survival up to 24 hours with TAH

Question 3

1969

Answer 3

– Cooley
 1st used a TAH to temporarily support a patient to transplant
 47yo man with failure to wean from CPB s/p LV Aneurysm repair
 TAH had only been tested for up to 12 hours in an animal model
 Implanted the “Liotta Heart” which was a pneumatic device
 Supported the patient for 64 hours.

Question 4

University of Utah investigators

Answer 4

first in the world to implant a permanent TAH on 12/2/1982.
 Jarvik 7 TAH performed by Dr. William DeVries
 Implanted into Dr. Barney Clark, 61 yo dentist with end stage idiopathic dilated cardiomyopathy
 Died of complications from aspiration pneumonia, renal failure, colitis with septicemia.
 Was supported for 112 days.

Question 5

Out of the 5 patients that received permanent TAH under FDA trial, what was the longest survival

Answer 5

620 days

Question 6

1985

Answer 6

– Copeland at the University of Arizona

 1st planned TAH implant as a Bridge to Transplant (BTT)

Question 7

Total Artificial Heart

Answer 7

 Device implanted in Tucson had issues
with the manufacturer, so the FDA withdrew the FDA exemption for
implantation.
 Syncardia, Cardiowest – Tucson, AZ
 Drs. Olsen and Copeland revived the
model
 Modified and renamed – Cardiowest C70
 Received FDA approval as a BTT in 2004

Question 8

Syncardia TAH

Answer 8

 9.5 liters per minute through both ventricles
 After implant and stable, patient is moved to 1A , top of the list
 1000 implanted as of Feb 10, 2012
 6 moving parts – inflow and outflow valves, and the diaphragm
 In 30 years, no device failures
 All electronics outside the body
 Utilizes a pneumatic driver