Test 4b Flashcards
Veins vs. arteries: Thicker
Arteries
Veins vs. arteries: Lower pressure
Veins
Veins vs. arteries: Larger lumen
Veins
Veins vs. arteries: Valves to prevent back flow
Arteries/veins
Veins vs. arteries: thicker tunica media
Arteries
Veins vs. arteries: Deeper in body
Arteries
Veins vs. arteries: assisted by skeletal muscle activity
Veins
What do capillaries consist of?
One cell thick - tunica intima only
Interweaving of capillaries
Beds
Flow of blood through capillary bed
Microcirculation
Largest artery
Aorta
Where does aorta arise?
Left ventricle
4 parts of aorta
Ascending aorta, aortic arch, descending aorta, abdominal aorta
Largest veins
Superior/Inferior Vena Cava
Where do vena cavae converge?
Right atrium
What part of body does vena cavae drain from?
Upper and lower regions of body
How are nutrients, gases, and waste exchanged in a fetus?
Placenta
How many vessels does an umbilical cord have?
3 vessels
How many veins/arteries does an umbilical cord have?
1, 2
Part that allows blood to bypass the liver and enter inferior vena cava in a fetus?
Ductus venosus
Opening in the septum of atria that allows some blood to go directly from right to left atrium in a fetus
Foramen ovale
A short vessel that connects the pulmonary trunk and aorta in a fetus
Ductus arteriosus
After birth, what happens to foramen ovale?
Closes
After birth, what does the ductus arteriosus collapse into?
Ligamentum arteriosum
Narrowing of arteries due to build up of fatty plaques
Arteriosclerosis
2 vessels most affected by arteriosclerosis
Aorta and coronary arteries
Stationary blood clot
Thrombus
Blood clot that has broken off from vessel wall and travels
Embolus
Plaque build up inside coronary arteries that impedes blood flow to cardiac tissue
Coronary Artery Disease (CAD)
Removal of vessel from periphery which is used to re-establish better circulation of the heart by re-routing the blood flow around the blockage
Coronary Artery Bypass Graft (CAMBG)
Left ventricular heart failure that results in decreased cardiac output, increased pressure in left atrium, and increased pressure in pulmonary veins
Congestive Heart Failure (CHF)
During CHF, what happens to the lungs?
Increase in pressure, allowing fluid to seep into interstitial tissue causing edema
Right ventricular heart failure which results in increased pressure in right atrium and increased pressure in vena cavae
Cor Pulmonale
Disturbance in electrical system of heart where atria “quiver” more than contract
Atrial Fibrillation
2 things that can result from atrial fibrillation
Possibility of blood stagnation and clotting, and stroke
Living blood cells of blood
Formed elements
Nonliving fluid matrix of blood
Plasma
Percentage of blood that contains red blood cells
Hematocrit
% blood volume of erythrocytes
45%
% blood volume of leukocytes
> 1%
% blood volume of platelets
<1%
Red blood cells
Erythrocytes
White blood cells
Leukocytes
Cell fragments for clotting
Platelets
pH of blood
Slightly alkaline (7.35-7.45)
Temperature of blood
100.4 F
% blood volume of plasma
55%
What percent of plasma is water?
90%
How many different dissolved substances does plasma contain?
> 100
Molecule carrier, blood buffer, osmotic pressure of bloodstream regulator, keeps water in circulatory system, and nutritional marker
Albumin
Help stop blood loss when blood vessels are injured
Proteins
Protection from pathogens
Antibodies
What happens when pH of blood is too high or too low?
Body organs triggered to make adjustments (kidneys, lungs)
Main function of RBCs
Carry oxygen to all cells
3 cellular characteristics of RBCs
No nucleus, very few organelles, lack mitochondria
Iron bearing protein that transports oxygen in the blood
Hemoglobin
Cell shape of RBCs
Biconcave - flattened discs with thin centers on both sides
How many RBCs in one drop of blood?
5,000,000
How many molecules of hemoglobin does 1 RBC contain?
250,000,000
How many oxygens can a hemoglobin bind?
4
Decrease in oxygen carrying capacity of blood
Anemia
2 symptoms of anemia
Abnormally low RBC count, abnormal level of hemoglobin
Abnormal increase in the number of RBCs
Polycythemia
What is polycythemia an indication of?
Bone marrow cancer
Sudden hemorrhage
Hemorrhagic anemia
Lysis of RBCs due to bacterial infections
Hemolytic anemia
Lack of vitamin B12
Pernicious anemia
Lack of RBC production or destruction of RBC due to bone marrow cancer, XRT, or medications
Anaplastic anemia
Lack of iron intake in diet which depletes iron reserves needed to make hemoglobin
Iron deficient anemia
2 cellular characteristics of WBCs
Contains nucleus and organelles
WBCs slip into and out of blood vessels
Diapedesis
WBCs locate areas of tissue damage and infection by responding to chemicals of damaged cells
Positive chemotaxis
Method that WBCs move through tissue spaces
Ameboid motion
Excessive amount of WBCs
Leukocytosis
Abnormally low WBC count
Leukopenia
WBCs that contain granules in cytoplasm
Granulocytes
WBCs that lack granules in cytoplasm
Agranulocytes
What shape nuclei do granulocytes have?
Round lobes
What shape nuclei do a granulocytes have?
Spherical, oval, kidney shaped
Most numerous granulocytes
Neutrophils
What do neutrophils attack?
Bacteria/fungi
What kind of nucleus do neutrophils have?
Multi-lobed, fine granules
Red granules
Eosinophils
What do eosinophils attack
Parasitic worms and fight allergies
Rarest WBC that contain histamine granules
Basophils
What do basophils do?
Fight inflammation
Agranulocytes with large, dark nuclei
Lymphocytes
Where do lymphocytes reside?
Lymphatic tissue
Largest WBCs with U shaped nucleus
Monocytes
What do monocytes fight
Chronic infections
Cancer of bone marrow and countless WBCs are produced
Leukemia
What is wrong with WBCs made in a person with leukemia
Immature and not able to carry out normal function
Multi-nucleate cells that form platelets
Megakaryocytes
Abnormal bleeding due to low platelet count
Thrombocytopenia
Inability to make usual clotting factors
Liver problems
What can cause liver problems
Low vitamin K levels, hepatitis, cirrhosis
Hereditary bleeding disorder that results in a lack of any of the clotting factors
Hemophilia
Blood cell formation
Hematopoiesis
Where does hematopoiesis occur?
Red bone marrow/myeloid tissue
Common type of stem cell from which all blood cells arise
Hemocytoblast
2 types of cells formed by hemocytoblast
Lymphoid stem cell, myeloid stem cell
What do lymphoid stem cells produce?
Lymphocytes
What do myeloid stem cells produce?
All other formed elements
Young RBC that enter blood stream to start transporting oxygen
Reticulocyte
How long does it take for a RBC to become fully functional
3-5 days
Hormone that controls RBC production
Erythropoietin
What produces erythropoietin
Liver, kidneys
Prompt red bone marrow to turn out new WBCs and also summon other WBCs to protect the body
Colony stimulating factors (CSFs) and interleukins
Speeds up platelet production
Thrombopoietin
Stoppage of bleeding
Hemostasis
3 steps of response to injured tissue cells
Vascular spasms, platelet plug formation, coagulation/blood formation
Smooth muscle spasms
Vasoconstriction
What do platelets stick to?
Exposed underlying collagen
What do platelets do once they attach to collagen
Release chemicals to cause more vasospasms and attract more platelets to form platelet plug
What do injured tissues release to enhance clotting
Tissue factor (TF)
Converts prothrombin to thrombin
Prothrombin activator
What does thrombin join to in order to form fibrin
Fibrinogen
Makes mesh to trap RBCs to make a clot
Fibrin