Test 3 Intro to Nuclear Imaging Flashcards

1
Q

What are the main types of anatomical imaging?

A
  • MRI

- CT

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2
Q

What does anatomical imaging do?

A
  • provides information about morphology of tissues

- looking at bone structure, primary tumors

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3
Q

computed tomography

A
  • multiple xray exposure that are combined into a 3D image
  • measure transmission of xray via radiodensity
  • resolution: < 1mm
  • fast acquisition
  • cam be used with metallic implants
  • radiation dose: about 3 yrs of background radiation
  • relatively low costs
  • good for hard tissue
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4
Q

What is the difference of CT scan with and without contrast?

A
  • without contrast: looking at hard tissue, gives high resolution, high radiodensity
  • with contrast: can see embolism in arteries, etc
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5
Q

magnetic resonance imaging

A
  • uses powerful magnetic fields to measure elemental radiofrequency energy in a tissue
  • measures nuclear spin energy in a tissue
  • resolution: <1 mm
  • takes about 40-60 min to obtain
  • cost is twice as much at CT
  • good for soft tissue
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6
Q

nuclear imaging

A
  • use of radioactive substances to diagnose a disease

- radiation source is internal

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7
Q

SPECT

A
  • Single Photon Emission Computed Tomography
  • patient inject with radio-labeled probe -> cameras measure gamma rays emitted
  • radiotracers are chelated to the targeted moiety
  • resolution: 1cm
  • radiation dose: 1-3 years of background radiation
  • takes about 40 min
  • cost is relatively low
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8
Q

PET

A
  • Positron Emission Tomography
    -uses positron
    patient injected by radiolabled probe
  • resolution: 2mm
  • radiation: 8 years of background radiation
  • 30 min acquisition time
  • cost is twice as much as CT
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9
Q

What is attenuation?

A

the lower energy your photons is, the less it can transmit through your tissue

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10
Q

half value layer

A

thickness of the material at which the intensity of radiation entering it is reduced by one half

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11
Q

describe the relationship between photon keV and HVL

A

↑ photon keV = ↑ HVL

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12
Q

(99m)Technetium Radionuclide

A
  • keV: 140
  • half life: 6 Hours
  • modality: SPECT
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13
Q

(18)Fluorine

A
  • keV: 511
  • half life: 109 Min
  • modality: PET
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14
Q

What is the energy for positrometers?

A

511 keV

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15
Q

What are the three forms of imaging?

A
  • anatomical imaging
  • physiological imaging
  • molecular imaging
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16
Q

What can you see with anatomical imaging?

A
  • bones
  • tumors
  • vasculature
  • CT, MRI
17
Q

What can you see with physiological imaging?

A
  • blood flow
  • metabolism
  • pH
  • renal clearance
  • cancer imaging
  • perfusion
  • SPECT, PET, CT, MRI
18
Q

What can you see with molecular imaging?

A
  • receptor imaging (ex. checking for disease)
  • drug kinetics (ex. measuring drug response, biodistribution)
  • referred to as “biomarker imaging”
  • MRI, SPECT, PET