Test 2 Hematopoietic Growth Factors Flashcards
Where does formation take place?
- fetal stage: in the yolk
- last trimester: thymus, kidney, liver
- rest of population: bone
How does hematopoiesis change as we age?
the yellow bone marrow increases and blood production decreases
Hematopoietic growth factors (HGFs)
- Are generally glycoproteins
- Most are single chain polypeptides
- Each HGF is encoded by a specific gene
How can HGFs vary?
- molecular weight
- specificity
- biological activity
RBC function
hemoglobin in RBC transports most of the oxygen and part of the CO2 in the blood
WBC function
combath pathogens and other foreign substances that enter the body
neutrophil function
phagocytosis; destruction of bacteria
eosinophil function
combat effect of histamine in allergic reactions; destroy some parasites
basophil function
liberate heparin, histamine, and serotonin in allergic reactions that intensify the overall inflammatory response
lymphocyte function
mediate immune response
monocyte function
transforms into macrophage -> phagocytosis
platelet (thrombocyte) function
form platelet plug in hemostasis; release chemicals that promote vascular spasm and blood clotting
stems cells to HGF’s
stem cell -> myeloid stem cell -> (HGF acts here) -> CFU progenitor cells
G-CSF
- Granulocyte colony stimulating factor
- Increase neutrophils
- Filgrastim, Lenograstim, Pegfilgrastim
GM-CSF
- Granulocyte
macrophage colony stimulating factor - Increase neutrophils, eosinophils, monocytes
- Molgramostim (not in US), Sargramostim
