Test 2 Coagulation Factors Flashcards
1
Q
coagulopathy
A
any defect in blood clotting -> there is hyper and hypo; hyper leads to pulmonary embolism
2
Q
Hemophilia
A
- Excessive bleeding tendency
- X-chromosome linked recessive disorder
- 3 categories: Type A, B, C
3
Q
Type A Hemophilia
A
- Classical hemophilia
- 8 out of 10 males who have hemophelia has this
- Defective production or absence of factor VIII
4
Q
Type B Hemophilia
A
- occasionally, Christmas disease
- Defective production or absence of factor IX
5
Q
Type C Hemophilia
A
- Less common and is a mild bleeding disorder
- Deficiency of factor XI
6
Q
Where does the extrinsic and intrinsic pathway meet?
A
- Factor X
- FX activates fibrinogen to firbin
7
Q
Locations of extrinsic and intrinsic pathway
A
- Extrinsic: in blood
- Intrinsic: mostly in tissue
8
Q
Factor VIII
A
- Antihemophilic factor (AHF)
- glycoprotein
- cofactor in the activation of factor X by factor IXa
- requires Ca+2 and phospholipids
- cDNA encoding for factor VIII is expressed in mammalian cell lines
9
Q
brand names for rFactor VIII products
A
- Recombinate
- Xyntha
- Refacto
- Helixate
- Bioclate
- Advat
- Kogenate
10
Q
properties of rFactor VIII products
A
- Dosage must be individualized
- Risk of developing antibodies
11
Q
Recombinant factor IX
A
- Factor IX is activated by factor VIIa in the extrinsic pathway and by factor XIa in the intrinsic pathway
- Indicated for control and prevention of hemorrhagic events in hemophilia type B patients
12
Q
properties of rFactor IX products
A
BeneFix
13
Q
properties of rFactor IX products
A
- Activity is about 200 IU/mg
- Contraindicated in patients with known hypersensitivity to mouse, hamster or bovine proteins
- bolus is administered over a 10-15 minute period
14
Q
Recombinant factor VIIa
A
- serine protease glycoprotein
- no matter how hard you try to purify factor VII, it gets purified into its active form
- Used when antibodies (inhibitors) develop for factors VIII or IX
15
Q
production of recombinant factor VIIa
A
Produced in BHK cells with cDNA containing human factor VIIa gene
