Test 2 Coagulation Factors

Question 1

coagulopathy

Answer 1

any defect in blood clotting -> there is hyper and hypo; hyper leads to pulmonary embolism

Question 2

Hemophilia

Answer 2

• Excessive bleeding tendency
• X-chromosome linked recessive disorder
• 3 categories: Type A, B, C

Question 3

Type A Hemophilia

Answer 3

• Classical hemophilia
• 8 out of 10 males who have hemophelia has this
• Defective production or absence of factor VIII

Question 4

Type B Hemophilia

Answer 4

• occasionally, Christmas disease

- Defective production or absence of factor IX

Question 5

Type C Hemophilia

Answer 5

• Less common and is a mild bleeding disorder

- Deficiency of factor XI

Question 6

Where does the extrinsic and intrinsic pathway meet?

Answer 6

• Factor X

- FX activates fibrinogen to firbin

Question 7

Locations of extrinsic and intrinsic pathway

Answer 7

• Extrinsic: in blood

- Intrinsic: mostly in tissue

Question 8

Factor VIII

Answer 8

• Antihemophilic factor (AHF)
• glycoprotein
• cofactor in the activation of factor X by factor IXa
• requires Ca+2 and phospholipids
• cDNA encoding for factor VIII is expressed in mammalian cell lines

Question 9

brand names for rFactor VIII products

Answer 9

• Recombinate
• Xyntha
• Refacto
• Helixate
• Bioclate
• Advat
• Kogenate

Question 10

properties of rFactor VIII products

Answer 10

• Dosage must be individualized

- Risk of developing antibodies

Question 11

Recombinant factor IX

Answer 11

• Factor IX is activated by factor VIIa in the extrinsic pathway and by factor XIa in the intrinsic pathway
• Indicated for control and prevention of hemorrhagic events in hemophilia type B patients

Question 12

properties of rFactor IX products

Answer 12

BeneFix

Question 13

properties of rFactor IX products

Answer 13

• Activity is about 200 IU/mg
• Contraindicated in patients with known hypersensitivity to mouse, hamster or bovine proteins
• bolus is administered over a 10-15 minute period

Question 14

Recombinant factor VIIa

Answer 14

• serine protease glycoprotein
• no matter how hard you try to purify factor VII, it gets purified into its active form
• Used when antibodies (inhibitors) develop for factors VIII or IX

Question 15

production of recombinant factor VIIa

Answer 15

Produced in BHK cells with cDNA containing human factor VIIa gene

Question 16

brand names for rFactor VIIa products

Answer 16

NovoSeven

Question 17

properties of rFactor VIIa products

Answer 17

Contraindicated in patients with known hypersensitivity to mouse, hamster or bovine proteins