Test 1 Study Guide Flashcards
What kind of connections join epthelial cells tightly together?
junctional complexes
_______ trials maximize the number of test participants and include particpants of both sexes, different ethnic groups, and those who have health problems besides the ones the drug is designed to treat.
Phase III
Plasma freezes at?
-0.56 degrees C
What scientist won a Nobel Prize in Physiology or Medicine for his work with the digestive system
Pavlov
What are the main three parts of a neuron?
Cell body, axons and dendrites
In a postive feedback mechanism, the action of an effector is?
increased
The Na+/K pump transports __________ into the cell and ________ out of the cell.
2 K+ in
3 Na+ out
Osmotic pressure is a measure of the force needed to?
stop osmosis
Which of the following indirectly utilizes energy? Simple Diffusion Primary Active Transport Facilitated diffusion Secondary active transport
Secondary active transport
What type of cell signalling occurs through the extracellular matrix to nearby target cells?
paracrine signaling
What is necessary for a target cell to respond to a cell signalling molecule?
specific receptor proteins
Thermoregulation directly involves?
eccrine sweat glands
The resting membrane potential is closest to the equilibrum potential for?
potassium ions
Endocrine glands secrete ________ in response to specific stimuli
hormones
How much of the total body water content is in the intracellular compartment?
67%
An integrating center sends information to an?
effector
What are the cateogories of cell signalling molecules?
endocrine signalling
synaptic signalling
paracrine signalling
What protein is present in large amounts in connective tissue proper?
collagen
Which type of connective tissue is characterized by a liquid extracellular matrix
blood
What is the function of the steep Na+/K+ gradient across the cell membrane
Provides energy for coupled transport
Maintains osmotic pressure
creates electrochemical impulses
Which glucose carrier is activated by either insulin or excerise?
GLUT4
Why are cells in body organs generally within 100nanometers of a blood capillary?
to decrease mean diffusion time
Specialized unicellular glands found in columnar epithelium that secretes mucus are?
goblet cells
Which of the following cells do NOT normally have many aquaporinds in their plasma membranes?
skin
the ATPase enzyme?
hydrolyzes ATP into ADP and Pi
Diffusion _______ the entropy of a solution
increases
The rate of diffusion is influenced by?
the concentration gradient
membrane surface area
membrane permeability
The transport of molecules out of the urinary filtrate and into the blood is called?
reabsorption
The study of how disease or injury alters physiological processes is termed?
pathophysiology
All glands that secrete into the digestive tract are?
exocrine
A person who is dehydrated will?
have increased osmolality that causes thirst
plasma osmolality increases
hypothalimus stimulates release of ADH
The zygote (fertillized egg) before implantation has the ability to produce all the various types of cells found in the body, this ability is?
totipotent
Solutes that cannot freely pass through a membrane are said to be?
osmotically active
The transport maximum is related to the property known as?
saturation
The entire epidermis is replaced every?
2 weeks
Most cells have resting membrane potential between?
-65 mV and -85mV
______ are a class of transmembrane glycoproteins that bind to the components in the extracellular matric thereby acting as adhesion molecules as well as communicating between the cells and the matric.
integrins
What are the primary tissues of the body?
epithelium, nervous, muscular
Carrier proteins display which of the following characteristics? Saturation specificity competition all of the above
all of the above
Which regulatory molecule cannot enter its target cell?
both epinephrine and acetylcholine
Histological examinations of the membrane shows several layers of keratinized flattened tissue. The sample most likely came from?
epidermis of the skin
A cell placed in 10% dextrose solution would>
not change
What are examples of exocrine glands?
salivary glands
sweat glands
mucous glands
What glands are responsible for the lubrication of the skin?
sebaceous
Cerebral edema would be treated with a(an) ____________ intervenous solution of mannitol.
hypertonic
Intercalated disks couple ___________ cells both mechanically and electrically
cardiac muscle
True/False:
Desmosomes are a type of junctional complex
True
True/False:
The calcium pump is also an ATPase enzyme
True
True/False:
negative feedback results in a response that opposes that of the original stimulus
True
True/False:
Organs are typically comprised of groupings of the four primary tissues into structural and functional units
true
True/False:
Organs are typically composed of groupings of the four primary tissues into structural and functional units
true
True/False:
The term homeostasis was coined by Walter Cannon to describe the dynamic constancy of the internal enviroment
true
True/False:
Muscle found in association with blood vessels would be striated
False
True/False:
Bacteria are responsible for the characteristic body odor of apocrine sweat
true
True/False:
Intersitial fluid is made from blood plasma and returns to blood plasma
true
True/False:
Diffusion is more rapid in cells with microvilli compared to cells lacking microvilli
true
True/False:
Fat is a type of connective tissue
True
True/False:
A 10% dextrose solution is isotonic to plasma
False
True/False:
Epithelial membranes cover body surfaces and line the cavity of organs
True
Physiology comes from what two greek words?
physio meaning nature
logos meaning to study
Pharmaceutical drugs are designed to fix physiology when it?
deviates from the norm
Animal models are used when?
Animals are susceptable to the same disease or malady that humans experience
Phase I of a clinical trial involves
testing drugs on healthy humans
Phase II of a clinical trial involves?
some of the population who has disease/disorder
Phase IV of a clinical trial involves?
other potential uses of the drug
and example of this is viagra
originally used for treatment of high blood pressure
Phase III of a clinical trial involves?
Using populations who have other disorders, both sexes, ethnic groups and approval of the FDA
Who was Erasistratus?
the 1st physiologist who tried to apply physical laws to how the body functions
Who was Galan?
the most prominate physiologist of his time
who was harvey?
Discovered that the heart pumps blood through a closed system
Who was Bernard?
Came up with Milleu Interior (internal enviroment) maintains constant conditions
What did Cannon do?
Defined homeostasis
What is homeostasis?
dynamic constancy of internal enviroment
Lardstiener discovered?
the different blood types
Van Bearing discovered?
Antibodies and came up with a serum with antibodies that treated dipthera
Langley studied?
the automatic nervous system
Who disovered insulin?
Banting, Best, and Macleod
The Role of ATP was discovered by?
von Szent-Gypgi
What is a stimulus?
changes from normal conditions