TCR and MHC molecules Flashcards
Which of the following is not true in regards to major histocompatibility complex type I?
a. It is found on all nucleated cells
b. The peptide groove is located on the alpha chain
c. It presents peptides of approximately 8-11 amino acids in length
d. It consists of an alpha and beta chain that both insert into the cell membrane
d. It consists of an alpha and beta chain that both insert into the cell membrane
**true for MHC II
Which of the following is not true regarding major histocompatibility complex type II?
a. It is found on professional antigen presenting cells
b. It presents peptides of approximately 30+ amino acids in length
c. It consists of an alpha and beta chain that both insert into the cell membrane
d. The peptide groove is located in the alpha chain
d. The peptide groove is located in the alpha chain
**true for MHC I
Which of the following statements is false regarding MHC type I ?
a. It is found on all nucleated cells
b. It presents exogenous peptides to T helper cells
c. The peptide binding groove is located in the alpha chain
d. It is a heterodimer with an alpha and beta chain
e. All the above are true
b. It presents exogenous peptides to T helper cells
**true for MHC II
True/False: BCR can only recognize peptide antigens when they’re presented by MHC molecules.
False
**true for TCR, BCR directly recognize and bind antigen
Which of the following is not recognized by BCR?
a. Protein
b. Lipids
c. Carbohydrates
d. Nucleic acids
e. All the above are recognized
e. All the above are recognized
Which of the following is needed for signal transduction of TCR’s?
a. Alpha beta chains
b. Delta gamma chains
c. Accessory molecules
d. V and C domains
c. Accessory molecules
Which of the following is false regarding accessory molecules?
a. CD4 T helper co- receptors sense MHC II molecules and CD8 cytotoxic T cell co- recetpors sense MHC I molecules
b. CD3 is an integrin that docks the T cells to the APC
c. CD3 complex transduce signals
d. ITAMS that are found within the CD3 complex convey signals to the inside fo T cells so transcription and transduction can occur
b. CD3 is an integrin that docks the T cells to the APC
**CD11/ LFA-1
True/False: T cells don’t perform class switching or somatic hypermutation its only seen with B cells.
True
What is the term that occurs in a developing lymphocyte where gene segmentes are joined in random order resulting in various differnet region sequences so they bind to different antigens?
Somatic recombination
True/False: MHC molecules can only recognize protein antigens and present them to T cells.
True
What is the name of the disease where B and T cells are absent making the RAG proteins non-functional or have partial recombinase activity?
SCID/ severe combined immunodecifiency disease
Recombinase enzymes are coded for an antigen receptor by the ___ and ___ genes present on chromosome ___.
RAG 1 and RAG 2 presented on chromosome 11
**(recombination activating genes)
The autosomal recessive form of SCID is called ____, wehre patients suffer from opportunistic fungal, bacterial and viral infections.
Omenn syndrome
MHC class II molecules are found on the following cells except:
a. B cells
b. Macrophages
c. Dendritic cells
d. NK cells
d. NK cells
**found on APC cells (B cells, Langerhan cells, Macrophages, and dendritic cells)
True/False: RAG1 and RAG2 operate during gene rearrangement in both T and B cells.
True
