Immunoglobulins Flashcards
____ are plasma glycoproteins that are produced by plasma cells in response to an antigen.
Antibodies
What are the two forms that antibodies can be?
Soluble (released into circulation as Ab’s) or bound to B cell surfaces (BCR)
What accessory molecules aid in signal transduction of BCR’s?
Ig alpha and beta
What do Ig alpha and beta contain that is essential for signal transduction and activated by phosphorylation?
ITAM’s
Which of the following immunoglobulin subunits binds variably with the antigen and blocks active sites of toxins/ pathogens with associated molecules?
a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region
b. Fab fragment
Which of the following is found on one domain of the heavy and light chain genes and responsible for specific binding to an antigen?
a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region
c. Hypervariable region
Which of the following is a non-variable immunoglogic trigger that acts as a receptor for complement proteins?
a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region
a. Fc fragment
Which of the following is responsible for triggering and comprises three domains?
a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region
d. Constant region
Which of the following enhances phagocytosis by macrophages and PMN (opsonization)?
a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region
a. Fc fragment
The ___ region confers flexibity on an antibody molecule.
Hinge region
All classes have either ___ or ___ light chains.
Kappa, lambda
Which immunoglobulin class crosses the placenta to give developing fetus immunity?
a. IgA
b. IgG
c. IgD
d. IgE
b. IgG
Which of the following is presented as a monomer BCR and secreted as a pentamer in blood and can activate complement and cause agglutination of large particles?
a. IgA
b. IgG
c. IgM
d. IgE
c. IgM
Which of the following can bind to Fc receptors on macrophages and neutrophls to facilitate phagocytosis?
a. IgA
b. IgG
c. IgM
d. IgE
b. IgG
Which of the following is a monomer in serum and dimeric in secretions and helps in the trasfer of epithelial cells?
a. IgA
b. IgG
c. IgM
d. IgE
a. IgA
Which immunoglobulins are responsible for complement activation?
IgM and IgG
Which immunoglobulin is responsible for coating antigens with antibodies to enhance phagocytosis (opsonization)?
IgG
Which of the following is found in mucous, saliva, milk and tears?
a. IgA
b. IgG
c. IgM
d. IgE
a. IgA
Which of the following is the primary trigger of allergic reactions and defense against multicellular parasites?
a. IgA
b. IgG
c. IgM
d. IgE
d. IgE
Which immunoglobulins enhace phagocytosis and decrease the number of infectious units to be dealt with by performing agglutination?
IgM, IgG, IgA
Which of the following stimulate mast cells and basophils to release cytokines?
a. IgA
b. IgG
c. IgM
d. IgE
d. IgE
Which of the following is found on the sruface of BCR’s and can also be free in serum in small amounts?
a. IgA
b. IgG
c. IgM
d. IgD
d. IgD
Which of the following refers to an antibody of one antigen reacting with an unrelated antigen?
a. Avidity
b. Specificity
c. Cross reactivity
d. None of the above
c. Cross reactivity
____ antibodies have different antibodies produced against various antigens of single infectious agent and can activate many clones of B cells.
Polyclonal
What are monoclonal antibodies?
Ab’s derived from a single clone of B cells and have specificity for a single antigen
Which is the earliest antibody produced that can switch to any class with the same specificty?
IgM
What are the 5 heavy chain and immunoglobulin classes?
IgA (alpha) IgG (gamma) IgM (mu) IgD (delta) IgE (epsilon)
What occurs in stimulated proliferating B cells that is responsible for affinity mutation?
Somatic hypermutation
Bacterial exotoxins can be neutralized by all the following immunoglobulins except:
a. IgA
b. IgE
c. IgG
d. IgM
b. IgE
During normal B cell development, which of the following immunoglobulins is the frist to develop on the surface of the B cell?
a. IgM
b. IgG
c. IgA
d. IgD
e. IgE
a. IgM
Which immunoglobulin class can be found in a monomeric and dimeric form?
a. IgD
b. IgE
c. IgG
d. IgA
e. IgM
d. IgA
