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Immunology > Immunoglobulins > Flashcards

Immunoglobulins Flashcards

1
Q

____ are plasma glycoproteins that are produced by plasma cells in response to an antigen.

A

Antibodies

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2
Q

What are the two forms that antibodies can be?

A

Soluble (released into circulation as Ab’s) or bound to B cell surfaces (BCR)

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3
Q

What accessory molecules aid in signal transduction of BCR’s?

A

Ig alpha and beta

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4
Q

What do Ig alpha and beta contain that is essential for signal transduction and activated by phosphorylation?

A

ITAM’s

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5
Q

Which of the following immunoglobulin subunits binds variably with the antigen and blocks active sites of toxins/ pathogens with associated molecules?

a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region

A

b. Fab fragment

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6
Q

Which of the following is found on one domain of the heavy and light chain genes and responsible for specific binding to an antigen?

a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region

A

c. Hypervariable region

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7
Q

Which of the following is a non-variable immunoglogic trigger that acts as a receptor for complement proteins?

a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region

A

a. Fc fragment

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8
Q

Which of the following is responsible for triggering and comprises three domains?

a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region

A

d. Constant region

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9
Q

Which of the following enhances phagocytosis by macrophages and PMN (opsonization)?

a. Fc fragment
b. Fab fragment
c. Hypervariable region
d. Constant region

A

a. Fc fragment

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10
Q

The ___ region confers flexibity on an antibody molecule.

A

Hinge region

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11
Q

All classes have either ___ or ___ light chains.

A

Kappa, lambda

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12
Q

Which immunoglobulin class crosses the placenta to give developing fetus immunity?

a. IgA
b. IgG
c. IgD
d. IgE

A

b. IgG

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13
Q

Which of the following is presented as a monomer BCR and secreted as a pentamer in blood and can activate complement and cause agglutination of large particles?

a. IgA
b. IgG
c. IgM
d. IgE

A

c. IgM

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14
Q

Which of the following can bind to Fc receptors on macrophages and neutrophls to facilitate phagocytosis?

a. IgA
b. IgG
c. IgM
d. IgE

A

b. IgG

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15
Q

Which of the following is a monomer in serum and dimeric in secretions and helps in the trasfer of epithelial cells?

a. IgA
b. IgG
c. IgM
d. IgE

A

a. IgA

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16
Q

Which immunoglobulins are responsible for complement activation?

A

IgM and IgG

17
Q

Which immunoglobulin is responsible for coating antigens with antibodies to enhance phagocytosis (opsonization)?

A

IgG

18
Q

Which of the following is found in mucous, saliva, milk and tears?

a. IgA
b. IgG
c. IgM
d. IgE

A

a. IgA

19
Q

Which of the following is the primary trigger of allergic reactions and defense against multicellular parasites?

a. IgA
b. IgG
c. IgM
d. IgE

A

d. IgE

20
Q

Which immunoglobulins enhace phagocytosis and decrease the number of infectious units to be dealt with by performing agglutination?

A

IgM, IgG, IgA

21
Q

Which of the following stimulate mast cells and basophils to release cytokines?

a. IgA
b. IgG
c. IgM
d. IgE

A

d. IgE

22
Q

Which of the following is found on the sruface of BCR’s and can also be free in serum in small amounts?

a. IgA
b. IgG
c. IgM
d. IgD

A

d. IgD

23
Q

Which of the following refers to an antibody of one antigen reacting with an unrelated antigen?

a. Avidity
b. Specificity
c. Cross reactivity
d. None of the above

A

c. Cross reactivity

24
Q

____ antibodies have different antibodies produced against various antigens of single infectious agent and can activate many clones of B cells.

A

Polyclonal

25
Q

What are monoclonal antibodies?

A

Ab’s derived from a single clone of B cells and have specificity for a single antigen

26
Q

Which is the earliest antibody produced that can switch to any class with the same specificty?

A

IgM

27
Q

What are the 5 heavy chain and immunoglobulin classes?

A 
IgA (alpha)
IgG (gamma)
IgM (mu)
IgD (delta)
IgE (epsilon)
28
Q

What occurs in stimulated proliferating B cells that is responsible for affinity mutation?

A

Somatic hypermutation

29
Q

Bacterial exotoxins can be neutralized by all the following immunoglobulins except:

a. IgA
b. IgE
c. IgG
d. IgM

A

b. IgE

30
Q

During normal B cell development, which of the following immunoglobulins is the frist to develop on the surface of the B cell?

a. IgM
b. IgG
c. IgA
d. IgD
e. IgE

A

a. IgM

31
Q

Which immunoglobulin class can be found in a monomeric and dimeric form?

a. IgD
b. IgE
c. IgG
d. IgA
e. IgM

A

d. IgA

Immunology (9 decks)

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