Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > Lymphoid System > Flashcards

Lymphoid System Flashcards

1
Q

Which of the following is a primary/ central lymphoid organ?

a. Mucous associated lymphoid tissue
b. Gut associated lymphoid tissue
c. Spleen
d. Bone marrow
e. Lymph node

A

d. Bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which of the following is a signaling molecule for B cells?

a. CAM’s
b. VLA
c. SCF
d. VCAM’s

A

c. SCF (stem cell factor)

**the others are adhesion molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which immunoglobulin do immature B cells have receptors for?

a. IgD
b. IgA
c. IgM
d. IgG

A

c. IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The thymus has ___ which are immature pro B cells that left the bone marrow and invaded the cortex of the thymus through blood.

A

Thymocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

True/False: Cortical epithelial cells of the thymus have already been exposed to antigen that belongs to the body.

A

False

**Thymocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

True/False: Only mature T cells leave the thymus and populate peripheral lymphatic organs.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the adhesion molecule that attaches T cells to surface molecules?

a. Desmin
b. Cadherin
c. Integrin
d. Cellular adhesion molecules

A

c. Integrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the name of special entry sites for blood circulating lymphocytes that lead them to the peripheral lymphoid organs?

A

High endothelial venules (HEV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the three cells that make up the lymphoid system?

A

Lymphocytes
Accessory cells (APC)
Epithelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The lymphoid system involves cells involved in the ____ immune response (lymphocytes, accessory cells, APC) that are localized and concentrated in anatomically defined organs and tissues.

A

Adaptive immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Where are lymphoid stem cells produced in a very young fetus?

A

Yolk sac mesoderm and fetal liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where are lymphoid stem cells produced in older fetuses and neonates?

A

Bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which of the following is the primary lymphoid organs of B cell maturation in birds?

a. Bone marrow
b. Spleen
c. Bursa of Fabricious
d. Peyer’s patches

A

c. Bursa of Fabricious

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which of the folllowing is the primary lymphoid organ that is the site of T cell development and maturation?

a. Bone marrow
b. Peyer’s Patches
c. Thymus
d. Bursa of Fabricious

A

c. Thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which cytokine is important for the maturation and proliferation of thymocytes?

a. IL-10
b. IL-2
c. IL-6
d. IL-7

A

d. IL-7

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

True/False: Thymocytes whose TCR’s either cannoy recognize antigen -MHC complexes or whose TCR react strongly with self antigen - MHC complexes die by apoptosis.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Thymic involution begins within the ___ which may disappear completely whereas ____ remnants persist.

A

Cortex, medullary

18
Q

True/False: The majority of B cells in birds are going to die through apoptosis.

A

True

19
Q

Which of the following is true regarding stromal cells?

a. They secrete various cytokines that are required for T cell development
b. Responsible for the selection of mature B cells
c. Immature B cells that acquire B cell antigen receptors that recognize self proteins are allowed to die
d. All the above are true

A

c. Immature B cells that acquire B cell antigen receptors that recognize self proteins are allowed to die

20
Q

Where are peyer’s patches found?

A

Within the walls of all three segments of small intestine

21
Q

Which of the following is false?

a. Lymph node captures antigen from epithelium and connective tissue
b. Blood borne antigens are captured by APC’s in the spleen
c. Skin, respiratory tract and gastrointestinal tract are the 3 major portals of antigen entry into the body
d. All the above are true

A

d. All the above are true

22
Q

Which of the following is the only lymphatic organ with both afferent and efferent lymph vessels?

a. Spleen
b. Bone marrow
c. Thymus
d. Lymph nodes

A

d. Lymph nodes

23
Q

True/False: The paracortex of lymph nodes contains mostly B cells and the primary follicles contain mostly T cells.

A

False

**paracortex contain T cells and primary follicles contain mostly B cells

24
Q

Which of the following regarind the lymph node is false?

a. Germinal centers develop in response to antigenic stimulation of B cells
b. Lymphocytes leave the node through the high endothelial venules in the secondary follicles
c. Primary follicles mainly contain mature B cells, follicular dneditic cells and macrophages
d. Paracortex contain mostly T cells while the medulla contains mostly macropahges, antibody secreting plasma cells and some lymphocytes

A

b. Lymphocytes leave the node through the high endothelial venules in the secondary follicles

**lymphocytes enter the node from the circulation through high endothelial venules in the paracortex

25
Q

What is the largest secondary lymphoid organ where antibodies are produced?

A

Spleen

26
Q

True/False: The spleen also contains high endothelial venules to help filter blood.

A

False

***only secondary lymphoid organ its not found in is the spleen

27
Q

Which of the following is true?

a. HEV’s are found in all secondary lymphoid organs except lymph nodes
b. If a naive T cell doesn’t encounter an antigen it stays within the organ
c. When antigens enter the antigen specific lymphocyte is activated and changed into effector or memory cells
d. There is only a certain amount of lymphocytes that are moved into the nodes

A

c. When antigens enter the antigen specific lymphocyte is activated and changed into effector or memory cells

28
Q

True/False: Rearrangement of the immunoglobulin heavy chain gene must occur first before rearrangement of the immunoglobulin light chain gene.

A

True

29
Q

Which of the following leads to the production of the light chain protein and mu protein of the heavy chain?

a. Transcription of RNA
b. Splicing of mRNA
c. DJ joined DNA
d. Translation of chains

A

d. Translation of chains

30
Q

What signaling molecules transmit biochemical signals after the variable region of the BCR binds to its antigen?

a. CD79
b. IL-7
c. CD3
d. MHC II

A

a. CD79

31
Q

A B cell that sheds its pre B cell IgM receptor is known as an ____ B cell.

A

Immature

32
Q

Which of the following terms refers to a process that attempts to rescue a self reactive B cell from undergoing apoptosis by reactivating the RAG 1 and RAG 2 genes and begins further rearrangement of the light chain genes?

a. Anergy
b. Receptor editing
c. Deletion
d. Clonal ignorance

A

b. Receptor editing

33
Q

Which lymphatic organ does not involute?

a. Bursa of Fabricious
b. Spleen
c. Ileal Peyer’s patch
d. Thymus

A

b. Spleen

34
Q

Pluriportent stem cells differentiate to give rise to all blood cells. The stem cells reside primarily in the:

a. Spleen
b. Thymus
c. Bone marrow
d. Liver

A

c. Bone marrow

35
Q

Which of the following is considered a foreign antigen?

a. Viruses
b. Bacteria
c. Fungi
d. All the above

A

d. All the above

36
Q

WHich of the following do not influence the potency and diversity fo a host’s immune system response to an antigen and are not considered “best antigens”?

a. Foreign
b. Non-degradable
c. Molecularly large
d. Chemically complex

A

b. Non-degradable

37
Q

Tens of billions of B cells are generated every day in the bone marrow, how many survive?

a. 90%
b. 10%
c. 50%
d. 0%
e. 17%

A

c. 50%

38
Q

Which of the following is correct regarding where B and T cells mature, just prior to traveling to lymph nodes?

a. B cells mature in the thymus; T cells mature in the thyroid
b. B cells mature in bone marrow; T cells mature in thymus
c. B cells mature in the spleen; T cells mature in the Bursa of Fabricious
d. B cells mature in the thymus; T cells mature in the peyers patches

A

b. B cells mature in bone marrow; T cells mature in thymus

39
Q

In the event of re-infection with the same pathogen, which immune cell allows for a quick response?

a. Null cell
b. Helper T cell
c. Memory B cell
d. Plasma cell

A

c. Memory B cell

40
Q

Which of the following statements regarding the spleen is the least accurate?

a. It is considered a secondary lymphatic organ
b. It is the largest “lymph node” in the body
c. The spleen filters antigens from the blood
d. It combines the innate and adaptive immune system in a unique way
d. Naive lymphocytes migrate from the blood into the spleen through high endothelial venues (HEV)

A

d. Naive lymphocytes migrate from the blood into the spleen through high endothelial venues (HEV)

41
Q

Which of the following is not a T cell signaling molecule?

a. CD4/ CD8
b. CD28
c. CD3
d. CD17
e. zeta zeta molecules

A

d. CD17

42
Q

What is the T cell adhesion molecule?

A

Integrins

Immunology (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions