Antigen recognition

Question 1

The likelihood of an antigen becoming assocaited with MHC I or MHC II is determined by:

a. The recognition of alpha cells
b. The recognition of beta cells
c. The recognition by polysaccharides, lipids, and nucleic acids
d. Solely by the route through the cell

Answer 1

d. Solely by the route through the cell

Question 2

True/False: CD8 monitors the extracellular environment and CD4 monitors the intracellular environment.

Answer 2

False

**CD4 = extracellular, CD8 = intracellular

Question 3

CD4 recognize antigen presented on ____ and CD8 recognize antigen presented on the surface of ____.

Answer 3

CD4 - MHC I

CD8 - MHC II

Question 4

Which of the following is false?

a. The likelihood of an antigen becoming associated with MHC I or II is determined by the route of the cell
b. Polysaccharides, lipids and nucleic acids can attach to MHC molecules because they recognize alpha and beta cells
c. Innate immunity takes care of many antigens and microbtes and protective immunity can occur when a small number of B and T cells encounter an antigen
d. With cell mediated immunity TCR’s only recognize processed antigens where the antigen must be presented by MHC molecules on the surface of an APC

Answer 4

b. Polysaccharides, lipids and nucleic acids can attach to MHC molecules because they recognize alpha and beta cells

**can’t attach to MHC molecules bc they DON’T recognize alpha and beta cells, but they may recognize gamma and delta cells

Question 5

Stabilization of the TCR -MHC interction is done by forming a ____ complex.

Answer 5

Tripartite

Question 6

___ is found on the T lymphocyte and ___ is on the APC which will bind together to enhance T cell stimulation following antigen binding.

Answer 6

CD28 - T lymphocyte

B7 - APC

Question 7

____ is an integrin on the TCR that binds to ___ on the APC.

Answer 7

CD11/ LFA-1 : TCR integrin

CD54/ ICAM 1: on APC

Question 8

True/False: CD4 binding to the TCR on MHC II has a disulfide linked dimer.

Answer 8

False

**true for CD8 binding to the TCR on MHC I

Question 9

For a T cell to be activated ___ must bind to ___.

Answer 9

B7 must bind to CD28

Question 10

Which interleukin is responsible for triggering the T cell to proliferate/ divide and make more of itself?

a. IL-4
b. IL-6
c. IL-2
d. IL-12

Answer 10

c. IL-2

Question 11

Which interleukin is responsible for increasing vascular permeability and stimulating the production of IL-6?

a. IL-1
b. IL-2
c. IL-8
d. IL-12

Answer 11

a. IL-1

Question 12

Which interleukin activates neutrophils?

a. IL-1
b. IL-6
c. IL-8
d. IL-12

Answer 12

c. IL-8

Question 13

Which of the following interleukins acts on the liver to produce C reactive proteins that will cause inflammation?

a. IL-1
b. IL-6
c. IL-8
d. IL-12

Answer 13

b. IL-6

Question 14

Which interleukin activates NK cells and influences lymphocyte differentiation?

a. IL-1
b. IL-6
c. IL-8
d. IL-12

Answer 14

d. IL-12

Question 15

Antigen processing cleaves ___ into ___ that are the correct size for MHC I or MHC II moleclues

Answer 15

proteins into peptides

Question 16

Which of the following is false?

a. Antigen peptides of CD8 are synthesized in the cytosol and then carried into the ER by TAP
b. Viral proteins are tagged by ubiquitin and then processed through a proteasome
c. Phagolysosomes degrade antigens using acid hydrolase, ROS and Nitric oxide lysosomal components
d. Recognition of MHC II binding to CD8 is mediated by various receptors to recognize PAMP’s

Answer 16

d. Recognition of MHC II binding to CD8 is mediated by various receptors to recognize PAMP’s

**MHC II binds to CD4, and recognition and binding is mediate dby various receptors to recognize PAMP’s

Question 17

What activates T cells without attaching to the groove of MHC molecules meaning its non-specific?

Answer 17

Superantigens

Question 18

Lymphocytes are activated in the ___ near sites of infection and then effector cells migrate to the site of infection.

Answer 18

Lymph node

Question 19

Superantigens attach to the ____ domain of the beta chain of the TCR activating ___ numbers of T cells.

Answer 19

Variable domain, activates large numbers of T cells