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Immunology > Complement System > Flashcards

Complement System Flashcards

1
Q

Which of the following makes up C3 convertase of the alternative pathway?

a. C3bBb
b. C4bC2a
c. C3bBbC3b
d. C4bC2aC3b

A

a. C3bBb

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2
Q

Which of the following is the most abundant complement protein?

a. C4
b. C5b
c. C2
d. C3

A

d. C3

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3
Q

Proteins are synthezied by the ___ and ___ and normally found in plasma and interstitial fluid.

A

Liver and macrophages

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4
Q

Which of the following is important for opsonization?

a. C2
b. C3
c. C3b
d. C5 convertase

A

c. C3b

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5
Q

Which pathways have to do with adaptive immunity and which have to do with innate immunity?

A

Innate: Alternative and MBL/ Lectin Pathway
Adaptive: Classical Pathway

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6
Q

C1q has a higher affinity to bind to ____ since it has two Fc regions that are closely spaced together activating the sites.

A

IgM

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7
Q

How many globular heads of C1q have to bind to the immunoglobulin binding sites in order for there to be a confirmational change in C1r?

A

2 or more globular heads

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8
Q

Which of the following is the C3 convertase for the classical pathway?

a. C3bBb
b. C4bC2a
c. C3bBbC3b
d. C4bC2aC3b

A

b. C4bC2a

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9
Q

True/False: Usually the b component is larger than the a coponent except for C3a that is larger than C3b.

A

False

**only exception is C2: C2a > C2b

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10
Q

Anaphylatoxin occurs in ___ which binds to ___ and ___ triggering them to release their vasoreacitive compounds enhacing vasodilation and vasopermeability.

A

C3a which binds to basophils and mast cells

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11
Q

What is the potent anaphylaxtoin that is a chemoattractant for neutrophils?

A

C5a

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12
Q

Which of the following is the C5 convertase for the classical pathway?

a. C3bBb
b. C4bC2a
c. C3bBbC3b
d. C4bC2aC3b

A

d. C4bC2aC3b

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13
Q

True/False: The C3 convertase for the MBL/Lectin pathway is the same as the one from the classical pathway.

A

True

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14
Q

The membrane attach complex and lysis of the cells is formed by which of the following?

a. C3a
b. C3b
c. C5a
d. C9

A

d. C9

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15
Q

What are the two anaphylaxtoin components that increase vascular permeability and cause vasodilation?

A

C3a and C5a

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16
Q

Which of the following is responsible for opsonization of a cell leading to phagocytosis?

a. C3a
b. C3b
c. C5a
d. C9

A

b. C3b

17
Q

In the alternative pathway C3b binds to ___ which is then cleaved by ____ to make Ba and Bb.

A

C3b binds to Factor B and then is cleaved by Factor D

18
Q

True/False: Activation of the MBL/Lactin pathway is through spontaneous conversion of C3 to C3b within the body.

A

False

**true for Alternative pathway

19
Q

True/False: MBL is srtucurally similar to C1q.

A

True

Immunology (9 decks)

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