TCA's overall chemical strat Flashcards

1
Q

TCA

A

eukaryotic enzymes in the mitochondria. What must happen?
Need to have transporters involved.

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2
Q

Oxidation of C involves,,,

A

loss of Hydride or gain of bonds to O with ∆G saved in NADH, FADH2 and GTP.

GTP can be converted to ATP

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3
Q

net rxn TCA

A

OA formed in step 8 is used in step 1:
3 NAD+ + FAD + GDP + Pi + Acetyl-CoA + 2H2O —-> 3NADH + FADH2 + GTP + CoA + 3H+

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4
Q

Two phases of TCA

A

phase 1: Rxns 1-4… oxidative phase

phase 2: Rxns 5-8… Regenerative phase, are reversible.

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5
Q

What is the key idea/overall chem strat???

A

Acetyl-Coa oxidation in TCA will happen as it does chemically because need carbanion TS stabilized via a/b-keto acids.

Come back to this idea as you study.

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6
Q
A
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